Electrospun SF/GO/VEGF/GAS-LP scaffolds with synergistic sequential drug release and electrical stimulation for accelerated peripheral nerve regeneration

被引：2

作者：

Liu, Jiashuo ^{[1
]}

Xiang, Runzhi ^{[1
]}

Li, Hongtao ^{[1
]}

Zhu, Hong ^{[1
]}

Dang, Jiarui ^{[1
]}

Ran, Zhihui ^{[1
]}

Deng, Huan ^{[1
]}

Xu, Wenjin ^{[1
]}

Xiong, Chengjie ^{[2
]}

Huang, Zhijun ^{[1
]}

Xu, Peihu ^{[1
]}

Xu, Haixing ^{[1
]}

机构：

[1] Wuhan Univ Technol, Dept Chem Chem & Life Sci, Wuhan, Peoples R China

[2] Gen Hosp Cent Theater Command PLA, Orthoped Dept, Wuhan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2024年 / 73卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Drug release; electrical stimulation; graphene oxide; Nerve scaffold; silk fibroin; SILK FIBROIN; VEGF; VASCULARIZATION; BEHAVIOR; CONDUIT; FIBERS;

D O I：

10.1080/00914037.2023.2250050

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Here, a novel kind of composite scaffold was fabricated by loading vascular endothelial growth factor (VEGF) and gastrodin liposome (GAS-LP) into electrospun silk fibroin/graphene oxide(SF/GO)nanofibrous and silk fibroin sponge-filled, respectively. Our results demonstrated that VEGF and GAS exhibited different release patterns in vitro which VEGF showed rapid release rate in the first few days while GAS was released slowly and continuously as encapsulated in liposomes. The scaffolds realized the combination of intraneural vascularization drugs and electrical stimulation effectively, leading to enhanced growth of RSC96 cells. Furthermore, the scaffolds could protect RSC96 cells in an inflammatory environment.

引用

页码：1136 / 1148

页数：13

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