Biomimetic Scaffolds for Tendon Tissue Regeneration

被引:21
作者
Huang, Lvxing [1 ]
Chen, Le [2 ]
Chen, Hengyi [1 ]
Wang, Manju [3 ]
Jin, Letian [4 ]
Zhou, Shenghai [4 ]
Gao, Lexin [1 ]
Li, Ruwei [1 ]
Li, Quan [2 ]
Wang, Hanchang [4 ]
Zhang, Can [5 ]
Wang, Junjuan [2 ]
机构
[1] Hangzhou Med Coll, Sch Savaid Stomatol, Hangzhou 310000, Peoples R China
[2] Hangzhou Med Coll, Sch Basic Med Sci & Forens Med, Hangzhou 310000, Peoples R China
[3] Hangzhou Med Coll, Sch Pharm, Hangzhou 310000, Peoples R China
[4] Hangzhou Med Coll, Sch Med Imaging, Hangzhou 310000, Peoples R China
[5] Hunan Univ, Coll Biol, Dept Biomed Engn, Changsha 410082, Peoples R China
基金
中国国家自然科学基金;
关键词
tissue engineering; tendon regeneration; biomimetic scaffolds; regenerative medicine; MESENCHYMAL STEM-CELLS; BIODEGRADABLE POLYURETHANE SCAFFOLDS; KNITTED SILK SCAFFOLD; MARROW STROMAL CELLS; FORMATION IN-VITRO; ACHILLES-TENDON; BONE-MARROW; ENGINEERED TENDON; NANOFIBROUS SCAFFOLDS; ELECTROSPUN NANOFIBERS;
D O I
10.3390/biomimetics8020246
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Tendon tissue connects muscle to bone and plays crucial roles in stress transfer. Tendon injury remains a significant clinical challenge due to its complicated biological structure and poor self-healing capacity. The treatments for tendon injury have advanced significantly with the development of technology, including the use of sophisticated biomaterials, bioactive growth factors, and numerous stem cells. Among these, biomaterials that the mimic extracellular matrix (ECM) of tendon tissue would provide a resembling microenvironment to improve efficacy in tendon repair and regeneration. In this review, we will begin with a description of the constituents and structural features of tendon tissue, followed by a focus on the available biomimetic scaffolds of natural or synthetic origin for tendon tissue engineering. Finally, we will discuss novel strategies and present challenges in tendon regeneration and repair.
引用
收藏
页数:45
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