MiR-29b modulates DNA methylation in promoter region of miR-130b in mouse model of Diabetic nephropathy

被引：1

作者：

Gondaliya, Piyush ^{[1
]}

Jash, Kavya ^{[1
]}

Srivastava, Akshay ^{[2
]}

Kalia, Kiran ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res Ahmedabad, Dept Biotechnol, Gandhinagar 382355, Gujarat, India

[2] Natl Inst Pharmaceut Educ & Res Ahmedabad, Dept Med Devices, Gandhinagar 382355, Gujarat, India

来源：

JOURNAL OF DIABETES AND METABOLIC DISORDERS | 2023年 / 22卷 / 02期

关键词：

MiR-29b; MiR-130b; Diabetic nephropathy; DNA methylation; Renal fibrosis; RENAL FIBROSIS; MESENCHYMAL TRANSITION; PATHOGENESIS; CONTRIBUTES; EXPRESSION; MICRORNAS;

D O I：

10.1007/s40200-023-01208-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epigenetic modifications play a role in Diabetic Nephropathy (DN). Downregulation of miR-29b leads to modulation of DNA methylation via DNA methyl transferases (DNMTs) and hence exaggerated renal fibrosis in DN. Therefore, the main aim of the study was to evaluate effect of miR-29b expression in vivo on DNMTs, renal fibrosis, glomerular and tubular damage as well as renal morphology in DN. In order to explore the role of miR-29b in DNA methylation of other miRNAs, methylation profiling study was performed. It revealed that miR-29b was involved in methylation on of miR-130b on the cytosine guanine dinucleotides rich DNA (CpG) island 1 located on promoter region. In conclusion, miR-29b expression was found to modulate DNA methylation via DNMTs and regulate methylation of miR-130b. The result of this study provides a future direction to unveil role of miRNA expression in DNA methylation and its consequent effect on other miRNAs in DN.

引用

页码：1105 / 1115

页数：11

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