Predictors of cardiac involvement in idiopathic inflammatory myopathies

被引：7

作者：

Bandeira, Matilde ^{[1
,2
]}

Dourado, Eduardo ^{[1
,2
]}

Melo, Ana Teresa ^{[1
,2
]}

Martins, Patricia ^{[1
,2
]}

Fraga, Vanessa ^{[3
]}

Ferraro, Jose Luis ^{[4
]}

Saraiva, Andre ^{[5
]}

Sousa, Marlene ^{[5
]}

Parente, Hugo ^{[6
]}

Soares, Catarina ^{[6
]}

Correia, Ana Margarida ^{[7
]}

Almeida, Diogo Esperanca ^{[7
]}

Dinis, Sara Paiva ^{[8
]}

Pinto, Ana Sofia ^{[8
]}

Pinheiro, Filipe Oliveira ^{[9
]}

Rato, Maria Seabra ^{[9
]}

Beirao, Tiago ^{[10
]}

Samoes, Beatriz ^{[10
]}

Santos, Bernardo ^{[11
]}

Mazeda, Carolina ^{[11
]}

Chicharo, Ana Teodosio ^{[12
]}

Faria, Margarida ^{[13
]}

Neto, Agna ^{[13
]}

Lourenco, Maria Helena ^{[14
]}

Brites, Luisa ^{[15
]}

Rodrigues, Marilia ^{[15
]}

Silva-Dinis, Joana ^{[16
]}

Dias, Joao Madruga ^{[17
]}

Araujo, Filipe C. ^{[18
]}

Martins, Nadia ^{[19
]}

Couto, Maura ^{[19
]}

Valido, Ana ^{[20
]}

Santos, Maria Jose ^{[2
,3
]}

Barreira, Sofia Carvalho ^{[1
,2
]}

Fonseca, Joao Eurico ^{[1
,2
]}

Campanilho-Marques, Raquel ^{[1
,2
]}

机构：

[1] Ctr Hosp Univ Lisboa Norte, CAML, Serv Reumatol, Lisbon, Portugal

[2] Univ Lisbon, Unidade Invest Reumatol, Inst Med Mol, Fac Med,CAML, Lisbon, Portugal

[3] Hosp Garcia Orta, Serv Reumatol, Almada, Portugal

[4] Hosp Beatriz Angelo, Serv Reumatol, Loures, Portugal

[5] Ctr Hosp Univ Coimbra, Serv Reumatol, Coimbra, Portugal

[6] Unidade Local Saude Alto Minho, Serv Reumatol, Ponte do Lima, Portugal

[7] Hosp Braga, Serv Reumatol, Braga, Portugal

[8] Unidade Local Saude Guarda, Serv Reumatol, Guarda, Portugal

[9] Ctr Hosp Univ Sao Joao, Serv Reumatol, Porto, Portugal

[10] Ctr Hosp Vila Nova de Gaia Espinho, Serv Reumatol, Vila Nova De Gaia, Portugal

[11] Ctr Hosp Baixo Vouga, Serv Reumatol, Aveiro, Portugal

[12] Ctr Hosp Univ Algarve, Serv Reumatol, Faro, Portugal

[13] Hosp Nelio Mendonca, Serv Reumatol, Serv Saude Regiao Autonoma Madeira, Funchal, Portugal

[14] Ctr Hosp Lisboa Ocidental, Serv Reumatol, Lisbon, Portugal

[15] Ctr Hosp Leiria, Serv Reumatol, Leiria, Portugal

[16] Ctr Hosp Univ Lisboa Cent, Serv Reumatol, Lisbon, Portugal

[17] Ctr Hosp Medio Tejo, Serv Reumatol, Tomar, Portugal

[18] Hosp CUF Cascais, Serv Reumatol, Cascais, Portugal

[19] Ctr Hosp Tondela Viseu, Serv Reumatol, Viseu, Portugal

[20] Unidade Local Saude Litoral Alentejano, Serv Reumatol, Santiago Do Cacem, Portugal

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

idiopathic inflammatory myopathies; cardiac involvement; myocarditis; risk factors; biomarkers; predictors; MYOSITIS; AUTOANTIBODIES; POLYMYOSITIS; DERMATOMYOSITIS; MANIFESTATIONS;

D O I：

10.3389/fimmu.2023.1146817

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objectives: Idiopathic inflammatory myopathies ( IIM) are a group of rare disorders that can affect the heart. This work aimed to find predictors of cardiac involvement in IIM. Methods: Multicenter, open cohort study, including patients registered in the IIM module of the Rheumatic Diseases Portuguese Register (Reuma.pt/Myositis) until January 2022. Patients without cardiac involvement information were excluded. Myo(peri)carditis, dilated cardiomyopathy, conduction abnormalities, and/or premature coronary artery disease were considered. Results: 230 patients were included, 163 (70.9%) of whom were females. Thirteen patients (5.7%) had cardiac involvement. Compared with IIM patients without cardiac involvement, these patients had a lower bilateral manual muscle testing score (MMT) at the peak of muscle weakness [108.0 +/- 55.0 vs 147.5 +/- 22.0, p=0.008] and more frequently had oesophageal [6/12 (50.0%) vs 33/207 (15.9%), p=0.009] and lung [10/13 ( 76.9%) vs 68/216 ( 31.5%), p=0.001] involvements. Anti-SRP antibodies were more commonly identified in patients with cardiac involvement [3/11 (27.3%) vs 9/174 (5.2%), p= 0.026]. In the multivariate analysis, positivity for anti-SRP antibodies (OR 104.3, 95% CI: 2.54277.8, p=0.014) was a predictor of cardiac involvement, regardless of sex, ethnicity, age at diagnosis, and lung involvement. Sensitivity analysis confirmed these results. Conclusion: Anti-SRP antibodies were predictors of cardiac involvement in our cohort of IIM patients, irrespective of demographical characteristics and lung involvement. We suggest considering frequent screening for heart involvement in anti-SRP-positive IIM patients.

引用

页数：7

共 23 条

[1] Pathogenic Role of Anti-Signal Recognition Protein and Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase Antibodies in Necrotizing Myopathies: Myofiber Atrophy and Impairment of Muscle Regeneration in Necrotizing Autoimmune Myopathies [J].

Arouche-Delaperche, Louiza ;

Allenbach, Yves ;

Amelin, Damien ;

Preusse, Corinna ;

Mouly, Vincent ;

Mauhin, Wladimir ;

Tchoupou, Gaelle Dzangue ;

Drouot, Laurent ;

Boyer, Olivier ;

Stenzel, Werner ;

Butler-Browne, Gillian ;

Benveniste, Olivier .

ANNALS OF NEUROLOGY, 2017, 81 (04) :538-548

[2] In vivo pathogenicity of IgG from patients with anti-SRP or anti-HMGCR autoantibodies in immune-mediated necrotising myopathy [J].

Bergua, Cecile ;

Chiavelli, Helene ;

Allenbach, Yves ;

Arouche-Delaperche, Louiza ;

Arnoult, Christophe ;

Bourdenet, Gwladys ;

Jean, Laetitia ;

Zoubairi, Rachid ;

Guerout, Nicolas ;

Mahler, Michael ;

Benveniste, Olivier ;

Drouot, Laurent ;

Boyer, Olivier .

ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 (01) :131-139

[3] Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients [J].

Betteridge, Z. ;

Tansley, S. ;

Shaddick, G. ;

Chinoy, H. ;

Cooper, R. G. ;

New, R. P. ;

Lilleker, J. B. ;

Vencovsky, J. ;

Chazarain, L. ;

Danko, K. ;

Nagy-Vincze, M. ;

Bodoki, L. ;

Dastmalchi, M. ;

Ekholm, L. ;

Lundberg, I. E. ;

McHugh, N. ;

Mann, Herman ;

Krystufkova, Olga ;

Klein, Martin ;

Barochova, Tereza ;

Kubinova, Katerina ;

Lamb, Janine ;

Rothwell, Simon ;

Ahmed, Yasmeen ;

Armstrong, Raymond ;

Bernstein, Robert ;

Black, Carol ;

Bowman, Simon ;

Bruce, Ian ;

Butler, Robin ;

Carty, John ;

Chattopadhyay, Chandra ;

Chelliah, Easwaradhas ;

Clarke, Fiona ;

Dawes, Peter ;

Denton, Christopher ;

Devlin, Joseph ;

Edwards, Christopher ;

Emery, Paul ;

Fordham, John ;

Fraser, Alexander ;

Gaston, Hill ;

Gordon, Patrick ;

Griffiths, Bridget ;

Gunawardena, Harsha ;

Hall, Frances ;

Hanna, Michael ;

Harrison, Beverley ;

Hay, Elaine ;

Hilton-Jones, David .

JOURNAL OF AUTOIMMUNITY, 2019, 101 :48-55

[4]

Canhao H, 2011, ACTA REUMATOL PORT, V36, P45

[5] Antisynthetase syndrome or what else? Different perspectives indicate the need for new classification criteria [J].

Cavagna, Lorenzo ;

Castaneda, Santos ;

Scire, Carlo ;

Gonzalez-Gay, Miguel A. .

ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 (08)

[6] The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositis [J].

Chinoy, Hector ;

Fertig, Noreen ;

Oddis, Chester V. ;

Ollier, William E. R. ;

Cooper, Robert G. .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (10) :1345-1349

[7] Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays [J].

Damoiseaux, Jan ;

Vulsteke, Jean-Baptiste ;

Tseng, Chih-Wei ;

Platteel, Anouk C. M. ;

Piette, Yves ;

Shovman, Ora ;

Bonroy, Carolien ;

Hamann, Dorte ;

De Langhe, Ellen ;

Musset, Lucille ;

Chen, Yi-Hsing ;

Shoenfeld, Yehuda ;

Allenbach, Yves ;

Bossuyt, Xavier .

AUTOIMMUNITY REVIEWS, 2019, 18 (03) :293-305

[8] Long-term survival of patients with idiopathic inflammatory myopathies according to clinical features -: A longitudinal study of 162 cases [J].

Dankó, K ;

Ponyi, A ;

Constantin, T ;

Borgulya, G ;

Szegedi, G .

MEDICINE, 2004, 83 (01) :35-42

[9] CARDIAC INVOLVEMENT IN POLYMYOSITIS - CLINICOPATHOLOGIC STUDY OF 20 AUTOPSIED PATIENTS [J].

DENBOW, CE ;

LIE, JT ;

TANCREDI, RG ;

BUNCH, TW .

ARTHRITIS AND RHEUMATISM, 1979, 22 (10) :1088-1092

[10] Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities [J].

Diederichsen, L. P. ;

Simonsen, J. A. ;

Diederichsen, A. C. ;

Hvidsten, S. ;

Hougaard, M. ;

Junker, P. ;

Sondergaard, K. ;

Lundberg, I. E. ;

Tvede, N. ;

Sandgaard, N. C. F. ;

Christensen, A. F. ;

Dreyer, L. ;

Kay, S. ;

Eskerud, K. S. ;

Petersen, H. ;

Ejstrup, L. ;

Jacobsen, S. .

ARTHRITIS CARE & RESEARCH, 2016, 68 (07) :1012-1020

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