Live birth is not the only relevant outcome in research assessing assisted reproductive technology

被引：5

作者：

Wang, Zheng ^{[1
]}

Cantineau, Astrid E. P. ^{[1
]}

Hoek, Annemieke ^{[1
]}

van Eekelen, Rik ^{[2
]}

Mol, Ben W. ^{[3
,4
]}

Wang, Rui ^{[3
,5
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, Groningen, Netherlands

[2] Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam, Netherlands

[3] Monash Univ, Richie Ctr, Dept Obstet & Gynecol, Melbourne, Australia

[4] Univ Aberdeen, Sch Med Med Sci & Nutr, Aberdeen, Scotland

[5] Monash Univ, Dept Obstet & Gynecol, 246 Clayton Rd, Clayton, Vic 3168, Australia

来源：

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2023年 / 86卷

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Assisted reproductive technology; Live birth; Pregnancy loss; Infertility; Outcomes; IN-VITRO FERTILIZATION; OVARIAN HYPERSTIMULATION SYNDROME; FUTURE INFERTILITY RESEARCH; RANDOMIZED CONTROLLED-TRIAL; ADVERSE PREGNANCY OUTCOMES; TERM HEALTH OUTCOMES; EMBRYO-TRANSFER; COST-EFFECTIVENESS; CHILDREN BORN; INTRAUTERINE INSEMINATION;

D O I：

10.1016/j.bpobgyn.2022.102306

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In assisted reproductive technology (ART) research, live birth has been generally accepted as an important outcome, if not the most important one. However, it has been reported inconsistently in the literature and solely focusing on live birth can lead to misinterpretation of research findings. In this review, we provide an overview on the definitions of live birth, including various denominators and numerators use. We present a series of real clinical examples in ART research to demonstrate the impact of variations in live birth on research findings and the importance of other outcomes, including multiple pregnancy, pregnancy loss, time to pregnancy leading to live birth, other short and long term maternal and offspring health outcomes and cost effectiveness measures. We suggest that outcome choices in ART research should be tailored for the research questions. A holistic outcome assessment beyond live birth would provide a full picture to Best Practice & Research Clinical Obstetrics and Gynaecology 86 (2023) 102306 address research questions in ART in terms of effectiveness and safety, and thus facilitate evidence-based decision making. (c) 2023 Elsevier Ltd. All rights reserved.

引用

页数：11

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