An overview of analytical methods for quantification of paracetamol

Both the international names paracetamol (used in Europe) and acetaminophen (used in the United States) are official names in the case of the same chemical substance. In an attempt to exterminate worms in the 1880s, two teenage physicians acetanilide was administered to a patient at the University of Strasburg accidentally in place of naphthalene. They observed that even though the drug greatly lowered high fever, it possessed very little impact on intestinal parasites. After a year, Frederick Stearns and Co., a division of Sterling Drug Inc., started offering 500 mg of aspirin pills over the counter in Great Britain under the brand name panadol. A spectrophotometric approach based on continuous flow for detecting paracetamol in pharmaceuticals is described. Created a stability-indicating technique to use the TLC densitometry method to figure out how much paracetamol is in pharmaceutical preparations. An effective approach for detecting acetaminophen in pharmaceutical formulations using reverse-phase highperformance liquid chromatography was developed. At a flow rate of 1.78 ml/min, a combination of methanol and water (1:2 v/v) is employed with a C18 stationary phase, with spectrophotometric detection 193.3 nm. Created a method for determining paracetamol using differential pulse voltammetry at a carbon ionic liquid electrode. A carbon paste electrode (CPE) and carbon ionic liquid electrode (CILE) were both used to study how paracetamol behaves electrochemically in a 0.1 m acetate buffer solution (pH 4.6). For example, long-term alcohol abuse combined with concurrent usage of medications that cause enzyme induction, including barbiturates, or carbamazepine, could make paracetamol poisoning more likely.