Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

被引:9
作者
Bell, Victoria [1 ]
Varzakas, Theodoros [2 ]
Psaltopoulou, Theodora [3 ]
Fernandes, Tito [4 ,5 ]
机构
[1] Univ Coimbra, Fac Pharm, Polo Ciencias Saude, P-3000548 Coimbra, Portugal
[2] Univ Peloponnese, Dept Food Sci & Technol, Kalamata 24100, Greece
[3] Natl & Kapodistrian Univ Athens, Med Sch, Athens 11527, Greece
[4] Univ Lisbon, Fac Vet Med, CIISA, P-1649004 Lisbon, Portugal
[5] Lurio Univ, Nampula 3100, Mozambique
基金
英国科研创新办公室;
关键词
sickle cell; hemoglobin; anemia; microbiota; nutrition; vaso-occlusive crisis; HEMATOLOGY; 2020; GUIDELINES; AMERICAN SOCIETY; MOUSE MODELS; EDIBLE MUSHROOMS; HOST GENETICS; ANEMIA; CHILDREN; MICROBIOTA; SUPPLEMENTATION; GENOME;
D O I
10.3390/nu16020258
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a congenital blood disorder characterized by considerable phenotypic diversity. It comprises a group of disorders, with sickle cell anemia (SCA) being the most prevalent and serious genotype. Although there have been some systematic reviews of global data, worldwide statistics regarding SCD prevalence, morbidity, and mortality remain scarce. In developed countries with a lower number of sickle cell patients, cutting-edge technologies have led to the development of new treatments. However, in developing settings where sickle cell disease (SCD) is more prevalent, medical management, rather than a cure, still relies on the use of hydroxyurea, blood transfusions, and analgesics. This is a disease that affects red blood cells, consequently affecting most organs in diverse manners. We discuss its etiology and the advent of new technologies, but the aim of this study is to understand the various types of nutrition-related studies involving individuals suffering from SCD, particularly in Africa. The interplay of the environment, food, gut microbiota, along with their respective genomes collectively known as the gut microbiome, and host metabolism is responsible for mediating host metabolic phenotypes and modulating gut microbiota. In addition, it serves the purpose of providing essential nutrients. Moreover, it engages in direct interactions with host homeostasis and the immune system, as well as indirect interactions via metabolites. Nutrition interventions and nutritional care are mechanisms for addressing increased nutrient expenditures and are important aspects of supportive management for patients with SCD. Underprivileged areas in Sub-Saharan Africa should be accompanied by efforts to define and promote of the nutritional aspects of SCD. Their importance is key to maintaining well-being and quality of life, especially because new technologies and products remain limited, while the use of native medicinal plant resources is acknowledged.
引用
收藏
页数:23
相关论文
共 50 条
  • [21] Sickle Cell Health Awareness, Perspectives, and Experiences (SHAPE) survey: Perspectives of adolescent and adult patients, caregivers, and healthcare professionals on the burden of sickle cell disease
    de Montalembert, Mariane
    Anderson, Alan
    Costa, Fernando F.
    Inusa, Baba P. D.
    Jastaniah, Wasil
    Kunz, Joachim B.
    Tinga, Biba
    Ingoli, Elvie
    James, John
    Hartfield, Regina
    Beaubrun, Anne
    Lartey, Belinda
    Odame, Isaac
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2024, 113 (02) : 172 - 182
  • [22] French guidelines for the management of adult sickle cell disease: 2015 update
    Habibi, A.
    Arlet, J. -B.
    Stankovik, K.
    Gellen-Dautremer, J.
    Ribeil, J. -A.
    Bartolucci, P.
    Lionnet, F.
    REVUE DE MEDECINE INTERNE, 2015, 36 : 5S3 - 5S84
  • [23] Pharmacological interventions for painful sickle cell vaso-occlusive crises in adults
    Cooper, Tess E.
    Hambleton, Ian R.
    Ballas, Samir K.
    Cashmore, Brydee A.
    Wiffen, Philip J.
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2019, (11):
  • [24] Evidence-based dental management in the new era of sickle cell disease A scoping review
    Hsu, Lewis L.
    Fan-Hsu, Judy
    JOURNAL OF THE AMERICAN DENTAL ASSOCIATION, 2020, 151 (09) : 668 - +
  • [25] The Mortality of Adults With Sickle Cell Disease at a Comprehensive Sickle Cell Center
    Afranie-Sakyi, Jennifer A.
    Randall, Eldrida
    Fasano, Ross
    Mclemore, Morgan L.
    El Rassi, Fuad
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2025, 114 (04) : 663 - 671
  • [26] Sickle Cell Disease and Stroke
    Talahma, Murad
    Strbian, Daniel
    Sundararajan, Sophia
    STROKE, 2014, 45 (06) : E98 - E100
  • [27] Sickle cell in sickle cell disease in Latin America and the United States
    Huttle, Alexandra
    Maestre, Gladys E.
    Lantigua, Rafael
    Green, Nancy S.
    PEDIATRIC BLOOD & CANCER, 2015, 62 (07) : 1131 - 1136
  • [28] A Systematic Review of Medication Adherence Interventions in Pediatric Sickle Cell Disease
    Shih, Sharon
    Cohen, Lindsey L.
    JOURNAL OF PEDIATRIC PSYCHOLOGY, 2020, 45 (06) : 593 - 606
  • [29] Priapism is Associated with Sleep Hypoxemia in Sickle Cell Disease
    Roizenblatt, Marina
    Figueiredo, Maria Stella
    Cancado, Rodolfo Delfini
    Pollack-Filho, Frederico
    de Almeida Santos Arruda, Martha Mariana
    Vicari, Perla
    Sato, Joao Ricardo
    Tufik, Sergio
    Roizenblatt, Suely
    JOURNAL OF UROLOGY, 2012, 188 (04) : 1245 - 1251
  • [30] Treatments for priapismin boys andmen with sickle cell disease
    Chinegwundoh, Francis I.
    Smith, Sherie
    Anie, Kofi A.
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2017, (09):