Feasibility of a dietary intervention to modify gut microbial metabolism in patients with hematopoietic stem cell transplantation

被引：15

作者：

Riwes, Mary M. ^{[1
]}

Golob, Jonathan L. ^{[2
]}

Magenau, John ^{[1
]}

Shan, Mengrou ^{[3
]}

Dick, Gregory ^{[4
]}

Braun, Thomas ^{[5
]}

Schmidt, Thomas M. ^{[2
]}

Pawarode, Attaphol ^{[1
]}

Anand, Sarah ^{[1
]}

Ghosh, Monalisa ^{[1
]}

Maciejewski, John ^{[1
]}

King, Darren ^{[1
]}

Choi, Sung ^{[1
]}

Yanik, Gregory ^{[1
]}

Geer, Marcus ^{[1
]}

Hillman, Ethan ^{[2
]}

Lyssiotis, Costas A. ^{[3
]}

Tewari, Muneesh ^{[1
]}

Reddy, Pavan ^{[1
,6
]}

机构：

[1] Univ Michigan, Rogel Canc Ctr, Dept Internal Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med, Div Infect Dis, Ann Arbor, MI USA

[3] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI USA

[4] Univ Michigan, Dept Earth & Environm Sci, Ann Arbor, MI USA

[5] Univ Michigan, Dept Biostat, Ann Arbor, MI USA

[6] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Houston, TX 77030 USA

来源：

NATURE MEDICINE | 2023年 / 29卷 / 11期

关键词：

VERSUS-HOST-DISEASE; CHAIN FATTY-ACIDS; EXPRESSION; DIVERSITY; BUTYRATE; GVHD; PROBIOTICS; PREBIOTICS; DAMAGE;

D O I：

10.1038/s41591-023-02587-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evaluation of the impact of dietary intervention on gastrointestinal microbiota and metabolites after allogeneic hematopoietic stem cell transplantation (HCT) is lacking. We conducted a feasibility study as the first of a two-phase trial. Ten adults received resistant potato starch (RPS) daily from day -7 to day 100. The primary objective was to test the feasibility of RPS and its effect on intestinal microbiome and metabolites, including the short-chain fatty acid butyrate. Feasibility met the preset goal of 60% or more, adhering to 70% or more doses; fecal butyrate levels were significantly higher when participants were on RPS than when they were not (P < 0.0001). An exploratory objective was to evaluate plasma metabolites. We observed longitudinal changes in plasma metabolites compared to baseline, which were independent of RPS (P < 0.0001). However, in recipients of RPS, the dominant plasma metabolites were more stable compared to historical controls with significant difference at engraftment (P < 0.05). These results indicate that RPS in recipients of allogeneic HCT is feasible; in this study, it was associated with significant alterations in intestinal and plasma metabolites. A phase 2 trial examining the effect of RPS on graft-versus-host disease in recipients of allogeneic HCT is underway.

引用

页码：2805 / 2813

页数：16

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