Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review

被引:2
作者
Dong, Xiaoyang [1 ]
Tang, Yunliang [1 ]
Zhou, Yifan [1 ]
Feng, Zhen [1 ]
机构
[1] Nanchang Univ, Affiliated Hosp 1, Dept Rehabil Med, Nanchang 330006, Jiangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
disorders of consciousness; vagus nerve stimulaiton; transcutaneous auricular vagus nerve stimulation; vagus nerve magnetic modulation; vegetative state/unresponsive wakefulness state; minimally conscious state; systematic review; TRAUMATIC BRAIN-INJURY; MODULATION; EXPRESSION; STATE;
D O I
10.3389/fnins.2023.1257378
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
PurposeThe purpose of this study is to evaluate the efficacy and safety of stimulating the vagus nerve in patients with disorders of consciousness (DOCs).MethodsA comprehensive systematic review was conducted, encompassing the search of databases such as PubMed, CENTRAL, EMBASE and PEDro from their inception until July 2023. Additionally, manual searches and exploration of grey literature were performed. The literature review was conducted independently by two reviewers for search strategy, selection of studies, data extraction, and judgment of evidence quality according to the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM) Study Quality Scale.ResultsA total of 1,269 articles were retrieved, and 10 studies met the inclusion criteria. Among these, there were three case reports, five case series, and only two randomized controlled trials (RCTs). Preliminary studies have suggested that stimulation of vagus nerve can enhance the levels of DOCs in both vegetative state/unresponsive wakefulness state (VS/UWS) and minimally conscious state (MCS). However, due to a lack of high-quality RCTs research and evidence-based medical evidence, no definitive conclusion can be drawn regarding the intervention's effectiveness on consciousness level. Additionally, there were no significant adverse effects observed following stimulation of vagus nerve.ConclusionA definitive conclusion cannot be drawn from this systematic review as there was a limited number of eligible studies and low-quality evidence. The findings of this systematic review can serve as a roadmap for future research on the use of stimulation of vagus nerve to facilitate recovery from DOCs.
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页数:9
相关论文
共 42 条
[1]  
Ardeshna Nikesh I, 2016, Neurodiagn J, V56, P1
[2]   Vagus nerve stimulation, side effects, and long-term safety [J].
Ben-Menachem, E .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2001, 18 (05) :415-418
[3]   Chronic vagus nerve stimulation induces neuronal plasticity in the rat hippocampus [J].
Biggio, Francesca ;
Gorini, Giorgio ;
Utzeri, Cinzia ;
Olla, Pierluigi ;
Marrosu, Francesco ;
Mocchetti, Italo ;
Follesa, Paolo .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2009, 12 (09) :1209-1221
[4]   Randomized trial of transcutaneous auricular vagus nerve stimulation on patients with disorders of consciousness: A study protocol [J].
Cheng, Lijuan ;
Sun, Lingxiu ;
Xu, Lu ;
Zhao, Falin ;
Liu, Xiaochen ;
Wang, Anqi ;
Di, Haibo ;
Cong, Yu-Sheng .
FRONTIERS IN NEUROLOGY, 2023, 14
[5]   Restoring consciousness with vagus nerve stimulation [J].
Corazzol, Martina ;
Lio, Guillaume ;
Lefevre, Arthur ;
Deiana, Gianluca ;
Tell, Laurence ;
Andre-Obadia, Nathalie ;
Bourdillon, Pierre ;
Guenot, Marc ;
Desmurget, Michel ;
Luaute, Jacques ;
Sirigu, Angela .
CURRENT BIOLOGY, 2017, 27 (18) :R994-R996
[6]   Behavioral scales variability in patients with prolonged disorders of consciousness [J].
Cortese, Maria Daniela ;
Vatrano, Martina ;
Arcuri, Francesco ;
Raso, Maria Girolama ;
Tonin, Paolo ;
Calabro, Rocco Salvatore ;
Riganello, Francesco .
NEUROLOGICAL SCIENCES, 2023, 44 (09) :3107-3122
[7]   Wake-promoting effects of vagus nerve stimulation after traumatic brain injury: upregulation of orexin-A and orexin receptor type 1 expression in the prefrontal cortex [J].
Dong, Xiao-yang ;
Feng, Zhen .
NEURAL REGENERATION RESEARCH, 2018, 13 (02) :244-251
[8]  
Dong XY, 2018, INT J CLIN EXP MED, V11, P4742
[9]  
Dostovic Zikrija, 2012, Cardiovasc Psychiatry Neurol, V2012, P429108, DOI 10.1155/2012/429108
[10]   Disorders of Consciousness [J].
Eapen, Blessen C. ;
Georgekutty, Jason ;
Subbarao, Bruno ;
Bavishi, Sheital ;
Cifu, David X. .
PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA, 2017, 28 (02) :245-258