The mediating role of negative symptoms in "secondary factors" determining social functioning in chronic schizophrenia

被引:1
作者
Hu, Na [1 ]
Li, Wei [1 ]
Deng, Hu [1 ]
Song, Jiaqi [1 ]
Yang, Hanxue [2 ]
Chai, Jiabao [1 ]
Huang, Wenqian [1 ]
Wang, Hong [1 ]
Zhou, Xuanzi [3 ]
Zhang, Pan [4 ]
He, Sushuang [1 ]
Cui, Yonghua [5 ]
Fan, Tengteng [6 ]
Li, Ying [5 ]
机构
[1] Peking Univ, Beijing Huilongguan Hosp, Huilongguan Clin Med Sch, Beijing, Peoples R China
[2] Beijing Language & Culture Univ, Sch Psychol, Beijing, Peoples R China
[3] Fengtai Maternal & Child Hlth Care Hosp, Beijing, Peoples R China
[4] Hebei Normal Univ, Dept Psychol, Shijiazhuang, Peoples R China
[5] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Children Hlth, Dept Psychiat, Beijing, Peoples R China
[6] Peking Univ, Inst Mental Hlth, NHC Key Lab Mental Hlth, Hosp 6,Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
来源
FRONTIERS IN PSYCHIATRY | 2023年 / 14卷
基金
中国国家自然科学基金;
关键词
secondary negative symptoms; chronic schizophrenia; depression; positive symptoms; social functioning; DEPRESSIVE SYMPTOMS; PSYCHOTIC DISORDER; GLOBAL ASSESSMENT; SCALE; VALIDITY; RELIABILITY; RESOURCES; SEVERITY; PEOPLE; APATHY;
D O I
10.3389/fpsyt.2023.1196760
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Chronic schizophrenia is significantly influenced by negative symptoms, with several known contributors to secondary negative symptoms. However, the impact of these factors and negative symptoms on social functioning warrants further exploration. Methods: We assessed the clinical symptoms, antipsychotic adverse reactions, and social functioning of 283 hospitalized patients with chronic schizophrenia using various standardized interviews and scales. We conducted multiple regression and mediation analyses to elucidate the impact of secondary factors on negative symptoms, and the relationship among these "secondary factors," negative symptoms, and social functioning. Results: Our findings identified depressive symptoms, extrapyramidal symptoms, and positive symptoms as significant contributors to secondary negative symptoms. We found that negative symptoms play a notable mediating role in the effect of depressive and positive symptoms on social functioning. However, the relationship between positive symptoms, negative symptoms, and social functioning proved to be intricate. Conclusion: Our findings propose that negative symptoms act as pivotal mediators in the correlation between "secondary factors" (including the depressive symptoms and positive symptoms) and social functioning. The treatment of chronic schizophrenia necessitates focusing on key factors such as depressive and positive symptoms, which might significantly contribute to the development of secondary negative symptoms. Further research is essential to clarify the complex relationship among positive symptoms, negative symptoms, and social functioning in schizophrenia.
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页数:8
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