Clonal hematopoiesis and inflammation-the perpetual cycle

被引：26

作者：

Avagyan, Serine ^{[1
]}

Zon, Leonard I. ^{[2
,3
]}

机构：

[1] Dana Farber Boston Childrens Hosp Canc & Blood Dis, Boston, MA 02115 USA

[2] Boston Childrens Hosp, Boston, MA 02215 USA

[3] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

TRENDS IN CELL BIOLOGY | 2023年 / 33卷 / 08期

关键词：

STEM-CELLS; SOMATIC MUTATIONS; SELF-RENEWAL; GENE; ALPHA; LEUKEMIA; COMMON; IMMUNODEFICIENCY; PROLIFERATION; ASSOCIATION;

D O I：

10.1016/j.tcb.2022.12.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact hematopoietic output, CH is associated with a heightened risk of progression to hematologic malignancies and with non-hematologic health manifestations, including cardiovascular disease and overall mortality. We focus on the evidence for the role of inflammation in establishing, maintaining and reciprocally being affected by CH. We describe the known pro-inflammatory signals associated with CH and preclinical studies that elucidated the cellular mechanisms involved. We review the evolving literature on early-onset CH in germline predisposition conditions and the possible role of immune dysregulation in this context.

引用

页码：695 / 707

页数：13

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