Iron-Catalyzed Synthesis of Benzosultams from N-Phenyl-N-(prop-2-yn-1-yl)benzenesulfonamide and Benzenesulfonyl Hydrazine

被引：8

作者：

Zhang, Mei ^{[1
]}

Yu, Xiao ^{[1
]}

Zhu, Wenjing ^{[1
]}

Liu, Yi ^{[1
]}

Zhang, Zenghui ^{[1
]}

Zhao, Jinbo ^{[1
]}

Xia, Chengcai ^{[1
]}

Li, Ke ^{[1
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Inst Pharmacol, Pharm Coll, Tai An 271016, Peoples R China

来源：

ORGANIC LETTERS | 2023年

关键词：

D O I：

10.1021/acs.orglett.2c04134

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel route for an iron-catalyzed tandem sulfonylation, C(sp2)-H activation, cyclization reaction which uses N-phenyl-N-(prop-2-yn-1-yl)benzenesulfonamide and benzenesulfonohydrazide to synthesize derivatives of (Z)-2-phenyl-4-((phenylsulfonyl)methylene)-3,4-dihydro-2H-benzo[e][1,2]thiazine 1,1-dioxide has been developed. The method features convenient operation and good functional group tolerance. In addition, it employs insensitive and inexpensive FeSO4 as the catalyst and provides a direct approach for the preparation of benzothiazides.

引用

页码：603 / 607

页数：5

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