Electrochemical Analysis of Antipsychotic Drug Quetiapine Fumarate Using Multi-walled Carbon Nanotube Modified Glassy Carbon Electrode

被引：2
作者：
Kaynar, Busra [1 ,2 ]
Ozturk, Gokce [1 ,2 ]
Kul, Dilek [1 ]
机构：
[1] Karadeniz Tech Univ, Fac Pharm, Dept Analyt Chem, TR-61080 Trabzon, Turkey
[2] Karadeniz Tech Univ, Inst Hlth Sci, TR-61080 Trabzon, Turkey
来源：
ELECTROANALYSIS | 2023年 / 35卷 / 03期
关键词：
Carbon nanotube; Glassy carbon electrode; Quetiapine; Validation; SENSITIVE VOLTAMMETRIC DETERMINATION; TANDEM MASS-SPECTROMETRY; ASCORBIC-ACID; HUMAN PLASMA; COMPOSITE; LIQUID; SENSOR; XR; PHARMACEUTICALS; METABOLITES;
D O I：
10.1002/elan.202200057
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Electrochemical properties of quetiapine fumarate were examined on the anodic direction with multi-walled carbon nanotube modified glassy carbon electrode using voltammetric methods. The ratio of multi-walled carbon nanotube has been optimized using its various concentrations. The oxidation process was found to be irreversible, and adsorption controlled. The linear ranges were determined as 4x10(-9)-2x10(-6) M for differential pulse stripping voltammetry and 2x10(-9)-2x10(-6) M for square-wave stripping voltammetry with detection limits of 8.07x10(-10) and 2.71x10(-10) M, respectively. The methods were validated and successfully applied for the analysis of quetiapine fumarate tablets. The groups responsible for the oxidation reaction of quetiapine fumarate were investigated with model substances.
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页数：9
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