Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank

被引：4

作者：

Wong, Jason Y. Y. ^{[1
]}

Blechter, Batel ^{[2
]}

Hubbard, Aubrey K. ^{[2
]}

Machiela, Mitchell J. ^{[2
]}

Shi, Jianxin ^{[2
]}

Gadalla, Shahinaz M. ^{[2
]}

Hu, Wei ^{[2
]}

Rahman, Mohammad L. ^{[2
]}

Rothman, Nathaniel ^{[2
]}

Lan, Qing ^{[2
]}

机构：

[1] NHLBI, Epidemiol & Community Hlth Branch, Bethesda, MD 20892 USA

[2] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA

来源：

THORAX | 2024年 / 79卷 / 03期

关键词：

Lung Cancer;

D O I：

10.1136/thorax-2023-220076

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

We investigated phenotypic leucocyte telomere length (LTL), genetically predicted LTL (gTL), and lung cancer risk among 371 890 participants, including 2829 incident cases, from the UK Biobank. Using multivariable Cox regression, we found dose-response relationships between longer phenotypic LTL (p-trendcontinuous=2.6x10-5), longer gTL predicted using a polygenic score with 130 genetic instruments (p-trendcontinuous=4.2x10-10), and overall lung cancer risk, particularly for adenocarcinoma. The associations were prominent among never smokers. Mendelian Randomization analyses supported causal associations between longer telomere length and lung cancer (HRper 1 SD gTL=1.87, 95% CI: 1.49 to 2.36, p=4.0x10-7), particularly adenocarcinoma (HRper 1 SD gTL=2.45, 95%CI: 1.69 to 3.57, p=6.5x10-6).

引用

页码：274 / 278

页数：5

共 10 条

[1] Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank [J].

Codd, V ;

Denniff, M. ;

Swinfield, C. ;

Warner, S. C. ;

Papakonstantinou, M. ;

Sheth, S. ;

Nanus, D. E. ;

Budgeon, C. A. ;

Musicha, C. ;

Bountziouka, V ;

Wang, Q. ;

Bramley, R. ;

Allara, E. ;

Kaptoge, S. ;

Stoma, S. ;

Jiang, T. ;

Butterworth, A. S. ;

Wood, A. M. ;

Di Angelantonio, E. ;

Thompson, J. R. ;

Danesh, J. N. ;

Nelson, C. P. ;

Samani, N. J. .

NATURE AGING, 2022, 2 (02) :170-+

[2] Polygenic basis and biomedical consequences of telomere length variation [J].

Codd, Veryan ;

Wang, Qingning ;

Allara, Elias ;

Musicha, Crispin ;

Kaptoge, Stephen ;

Stoma, Svetlana ;

Jiang, Tao ;

Hamby, Stephen E. ;

Braund, Peter S. ;

Bountziouka, Vasiliki ;

Budgeon, Charley A. ;

Denniff, Matthew ;

Swinfield, Chloe ;

Papakonstantinou, Manolo ;

Sheth, Shilpi ;

Nanus, Dominika E. ;

Warner, Sophie C. ;

Wang, Minxian ;

Khera, Amit V. ;

Eales, James ;

Ouwehand, Willem H. ;

Thompson, John R. ;

Di Angelantonio, Emanuele ;

Wood, Angela M. ;

Butterworth, Adam S. ;

Danesh, John N. ;

Nelson, Christopher P. ;

Samani, Nilesh J. .

NATURE GENETICS, 2021, 53 (10) :1425-+

[3] Nested case-control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial [J].

Doherty, Jennifer Anne ;

Grieshober, Laurie ;

Houck, John R. ;

Barnett, Matt J. ;

Tapsoba, Jean De Dieu ;

Thornquist, Mark D. ;

Wang, Ching-Yun ;

Goodman, Gary E. ;

Chen, Chu .

BRITISH JOURNAL OF CANCER, 2018, 118 (11) :1513-1517

[4] Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study [J].

Haycock, Philip C. ;

Burgess, Stephen ;

Nounu, Aayah ;

Zheng, Jie ;

Okoli, George N. ;

Bowden, Jack ;

Wade, Kaitlin Hazel ;

Timpson, Nicholas J. ;

Evans, David M. ;

Willeit, Peter ;

Aviv, Abraham ;

Gaunt, Tomr. ;

Hemani, Gibran ;

Mangino, Massimo ;

Ellis, Hayley Patricia ;

Kurian, Kathreena M. ;

Pooley, Karen A. ;

Eeles, Rosalind A. ;

Lee, Jeffrey E. ;

Fang, Shenying ;

Chen, Wei V. ;

Law, Matthew H. ;

Bowdler, Lisa M. ;

Iles, Mark M. ;

Yang, Qiong ;

Worrall, Bradford B. ;

Markus, Hugh Stephen ;

Hung, Rayjean J. ;

Amos, Chris I. ;

Spurdle, Amanda B. ;

Thompson, Deborah J. ;

O'Mara, Tracy A. ;

Wolpin, Brian ;

Amundadottir, Laufey ;

Stolzenberg-Solomon, Rachael ;

Trichopoulou, Antonia ;

Onland-Moret, Charlotte ;

Lund, Eiliv ;

Duell, Eric J. ;

Canzian, Federico ;

Severi, Gianluca ;

Overvad, Kim ;

Gunter, Marc J. ;

Tumino, Rosario ;

Svenson, Ulrika ;

van Rij, Andre ;

Baas, Annette F. ;

Bown, Matthew J. ;

Samani, Nilesh J. ;

van t'Hof, Femke N. G. .

JAMA ONCOLOGY, 2017, 3 (05) :636-651

[5] Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers [J].

Kachuri, Linda ;

Saarela, Olli ;

Bojesen, Stig Egil ;

Smith, George Davey ;

Liu, Geoffrey ;

Landi, Maria Teresa ;

Caporaso, Neil E. ;

Christiani, David C. ;

Johansson, Mattias ;

Panico, Salvatore ;

Overvad, Kim ;

Trichopoulou, Antonia ;

Vineis, Paolo ;

Scelo, Ghislaine ;

Zaridze, David ;

Wu, Xifeng ;

Albanes, Demetrius ;

Diergaarde, Brenda ;

Lagiou, Pagona ;

Macfarlane, Gary J. ;

Aldrich, Melinda C. ;

Tardon, Adonina ;

Rennert, Gad ;

Olshan, Andrew F. ;

Weissler, Mark C. ;

Chen, Chu ;

Goodman, Gary E. ;

Doherty, Jennifer A. ;

Ness, Andrew R. ;

Bickeboeller, Heike ;

Wichmann, H-Erich ;

Risch, Angela ;

Field, John K. ;

Teare, M. Dawn ;

Kiemeney, Lambertus A. ;

van der Heijden, Erik H. F. M. ;

Carroll, June C. ;

Haugen, Aage ;

Zienolddiny, Shanbeh ;

Skaug, Vidar ;

Wunsch-Filho, Victor ;

Tajara, Eloiza H. ;

Moyses, Raquel Ayoub ;

Nunes, Fabio Daumas ;

Lam, Stephen ;

Eluf-Neto, Jose ;

Lacko, Martin ;

Peters, Wilbert H. M. ;

Le Marchand, Loic ;

Duell, Eric J. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2019, 48 (03) :751-766

[6] Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia [J].

Machiela, Mitchell J. ;

Hsiung, Chao Agnes ;

Shu, Xiao-Ou ;

Seow, Wei Jie ;

Wang, Zhaoming ;

Matsuo, Keitaro ;

Hong, Yun-Chul ;

Seow, Adeline ;

Wu, Chen ;

Hosgood, H. Dean, III ;

Chen, Kexin ;

Wang, Jiu-Cun ;

Wen, Wanqing ;

Cawthon, Richard ;

Chatterjee, Nilanjan ;

Hu, Wei ;

Caporaso, Neil E. ;

Park, Jae Yong ;

Chen, Chien-Jen ;

Kim, Yeul Hong ;

Kim, Young Tae ;

Landi, Maria Teresa ;

Shen, Hongbing ;

Lawrence, Charles ;

Burdett, Laurie ;

Yeager, Meredith ;

Chang, I-Shou ;

Mitsudomi, Tetsuya ;

Kim, Hee Nam ;

Chang, Gee-Chen ;

Bassig, Bryan A. ;

Tucker, Margaret ;

Wei, Fusheng ;

Yin, Zhihua ;

An, She-Juan ;

Qian, Biyun ;

Lee, Victor Ho Fun ;

Lu, Daru ;

Liu, Jianjun ;

Jeon, Hyo-Sung ;

Hsiao, Chin-Fu ;

Sung, Jae Sook ;

Kim, Jin Hee ;

Gao, Yu-Tang ;

Tsai, Ying-Huang ;

Jung, Yoo Jin ;

Guo, Huan ;

Hu, Zhibin ;

Hutchinson, Amy ;

Wang, Wen-Chang .

INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (02) :311-319

[7] Telomere Length in White Blood Cell DNA and Lung Cancer: A Pooled Analysis of Three Prospective Cohorts [J].

Seow, Wei Jie ;

Cawthon, Richard M. ;

Purdue, Mark P. ;

Hu, Wei ;

Gao, Yu-Tang ;

Huang, Wen-Yi ;

Weinstein, Stephanie J. ;

Ji, Bu-Tian ;

Virtamo, Jarmo ;

Hosgood, H. Dean, III ;

Bassig, Bryan A. ;

Shu, Xiao-Ou ;

Cai, Qiuyin ;

Xiang, Yong-Bing ;

Min, Shen ;

Chow, Wong-Ho ;

Berndt, Sonja I. ;

Kim, Christopher ;

Lim, Unhee ;

Albanes, Demetrius ;

Caporaso, Neil E. ;

Chanock, Stephen ;

Zheng, Wei ;

Rothman, Nathaniel ;

Lan, Qing .

CANCER RESEARCH, 2014, 74 (15) :4090-4098

[8] UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age [J].

Sudlow, Cathie ;

Gallacher, John ;

Allen, Naomi ;

Beral, Valerie ;

Burton, Paul ;

Danesh, John ;

Downey, Paul ;

Elliott, Paul ;

Green, Jane ;

Landray, Martin ;

Liu, Bette ;

Matthews, Paul ;

Ong, Giok ;

Pell, Jill ;

Silman, Alan ;

Young, Alan ;

Sprosen, Tim ;

Peakman, Tim ;

Collins, Rory .

PLOS MEDICINE, 2015, 12 (03)

[9] Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed [J].

Taub, Margaret A. ;

Conomos, Matthew P. ;

Keener, Rebecca ;

Iyer, Kruthika R. ;

Weinstock, Joshua S. ;

Yanek, Lisa R. ;

Lane, John ;

Miller-Fleming, Tyne W. ;

Brody, Jennifer A. ;

Raffield, Laura M. ;

McHugh, Caitlin P. ;

Jain, Deepti ;

Gogarten, Stephanie M. ;

Laurie, Cecelia A. ;

Keramati, Ali ;

Arvanitis, Marios ;

Smith, Albert, V ;

Heavner, Benjamin ;

Barwick, Lucas ;

Becker, Lewis C. ;

Bis, Joshua C. ;

Blangero, John ;

Bleecker, Eugene R. ;

Burchard, Esteban G. ;

Celedon, Juan C. ;

Chang, Yen Pei C. ;

Custer, Brian ;

Darbar, Dawood ;

de las Fuentes, Lisa ;

DeMeo, Dawn L. ;

Freedman, Barry, I ;

Garrett, Melanie E. ;

Gladwin, Mark T. ;

Heckbert, Susan R. ;

Hidalgo, Bertha A. ;

Irvin, Marguerite R. ;

Islam, Talat ;

Johnson, W. Craig ;

Kaab, Stefan ;

Launer, Lenore ;

Lee, Jiwon ;

Liu, Simin ;

Moscati, Arden ;

North, Kari E. ;

Peyser, Patricia A. ;

Rafaels, Nicholas ;

Seidman, Christine ;

Weeks, Daniel E. ;

Wen, Fayun ;

Wheeler, Marsha M. .

CELL GENOMICS, 2022, 2 (01)

[10] Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study [J].

Yuan, Jian-Min ;

Beckman, Kenneth B. ;

Wang, Renwei ;

Bull, Caroline ;

Adams-Haduch, Jennifer ;

Huang, Joyce Y. ;

Jin, Aizhen ;

Opresko, Patricia ;

Newman, Anne B. ;

Zheng, Yun-Ling ;

Fenech, Michael ;

Koh, Woon-Puay .

INTERNATIONAL JOURNAL OF CANCER, 2018, 142 (11) :2234-2243

← 1 →

共 10 条

[1] Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank [J].

Codd, V ;

Denniff, M. ;

Swinfield, C. ;

Warner, S. C. ;

Papakonstantinou, M. ;

Sheth, S. ;

Nanus, D. E. ;

Budgeon, C. A. ;

Musicha, C. ;

Bountziouka, V ;

Wang, Q. ;

Bramley, R. ;

Allara, E. ;

Kaptoge, S. ;

Stoma, S. ;

Jiang, T. ;

Butterworth, A. S. ;

Wood, A. M. ;

Di Angelantonio, E. ;

Thompson, J. R. ;

Danesh, J. N. ;

Nelson, C. P. ;

Samani, N. J. .

NATURE AGING, 2022, 2 (02) :170-+

[2] Polygenic basis and biomedical consequences of telomere length variation [J].

Codd, Veryan ;

Wang, Qingning ;

Allara, Elias ;

Musicha, Crispin ;

Kaptoge, Stephen ;

Stoma, Svetlana ;

Jiang, Tao ;

Hamby, Stephen E. ;

Braund, Peter S. ;

Bountziouka, Vasiliki ;

Budgeon, Charley A. ;

Denniff, Matthew ;

Swinfield, Chloe ;

Papakonstantinou, Manolo ;

Sheth, Shilpi ;

Nanus, Dominika E. ;

Warner, Sophie C. ;

Wang, Minxian ;

Khera, Amit V. ;

Eales, James ;

Ouwehand, Willem H. ;

Thompson, John R. ;

Di Angelantonio, Emanuele ;

Wood, Angela M. ;

Butterworth, Adam S. ;

Danesh, John N. ;

Nelson, Christopher P. ;

Samani, Nilesh J. .

NATURE GENETICS, 2021, 53 (10) :1425-+

[3] Nested case-control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial [J].

Doherty, Jennifer Anne ;

Grieshober, Laurie ;

Houck, John R. ;

Barnett, Matt J. ;

Tapsoba, Jean De Dieu ;

Thornquist, Mark D. ;

Wang, Ching-Yun ;

Goodman, Gary E. ;

Chen, Chu .

BRITISH JOURNAL OF CANCER, 2018, 118 (11) :1513-1517

[4] Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study [J].

Haycock, Philip C. ;

Burgess, Stephen ;

Nounu, Aayah ;

Zheng, Jie ;

Okoli, George N. ;

Bowden, Jack ;

Wade, Kaitlin Hazel ;

Timpson, Nicholas J. ;

Evans, David M. ;

Willeit, Peter ;

Aviv, Abraham ;

Gaunt, Tomr. ;

Hemani, Gibran ;

Mangino, Massimo ;

Ellis, Hayley Patricia ;

Kurian, Kathreena M. ;

Pooley, Karen A. ;

Eeles, Rosalind A. ;

Lee, Jeffrey E. ;

Fang, Shenying ;

Chen, Wei V. ;

Law, Matthew H. ;

Bowdler, Lisa M. ;

Iles, Mark M. ;

Yang, Qiong ;

Worrall, Bradford B. ;

Markus, Hugh Stephen ;

Hung, Rayjean J. ;

Amos, Chris I. ;

Spurdle, Amanda B. ;

Thompson, Deborah J. ;

O'Mara, Tracy A. ;

Wolpin, Brian ;

Amundadottir, Laufey ;

Stolzenberg-Solomon, Rachael ;

Trichopoulou, Antonia ;

Onland-Moret, Charlotte ;

Lund, Eiliv ;

Duell, Eric J. ;

Canzian, Federico ;

Severi, Gianluca ;

Overvad, Kim ;

Gunter, Marc J. ;

Tumino, Rosario ;

Svenson, Ulrika ;

van Rij, Andre ;

Baas, Annette F. ;

Bown, Matthew J. ;

Samani, Nilesh J. ;

van t'Hof, Femke N. G. .

JAMA ONCOLOGY, 2017, 3 (05) :636-651

[5] Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers [J].

Kachuri, Linda ;

Saarela, Olli ;

Bojesen, Stig Egil ;

Smith, George Davey ;

Liu, Geoffrey ;

Landi, Maria Teresa ;

Caporaso, Neil E. ;

Christiani, David C. ;

Johansson, Mattias ;

Panico, Salvatore ;

Overvad, Kim ;

Trichopoulou, Antonia ;

Vineis, Paolo ;

Scelo, Ghislaine ;

Zaridze, David ;

Wu, Xifeng ;

Albanes, Demetrius ;

Diergaarde, Brenda ;

Lagiou, Pagona ;

Macfarlane, Gary J. ;

Aldrich, Melinda C. ;

Tardon, Adonina ;

Rennert, Gad ;

Olshan, Andrew F. ;

Weissler, Mark C. ;

Chen, Chu ;

Goodman, Gary E. ;

Doherty, Jennifer A. ;

Ness, Andrew R. ;

Bickeboeller, Heike ;

Wichmann, H-Erich ;

Risch, Angela ;

Field, John K. ;

Teare, M. Dawn ;

Kiemeney, Lambertus A. ;

van der Heijden, Erik H. F. M. ;

Carroll, June C. ;

Haugen, Aage ;

Zienolddiny, Shanbeh ;

Skaug, Vidar ;

Wunsch-Filho, Victor ;

Tajara, Eloiza H. ;

Moyses, Raquel Ayoub ;

Nunes, Fabio Daumas ;

Lam, Stephen ;

Eluf-Neto, Jose ;

Lacko, Martin ;

Peters, Wilbert H. M. ;

Le Marchand, Loic ;

Duell, Eric J. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2019, 48 (03) :751-766

Machiela, Mitchell J. ;

Hsiung, Chao Agnes ;

Shu, Xiao-Ou ;

Seow, Wei Jie ;

Wang, Zhaoming ;

Matsuo, Keitaro ;

Hong, Yun-Chul ;

Seow, Adeline ;

Wu, Chen ;

Hosgood, H. Dean, III ;

Chen, Kexin ;

Wang, Jiu-Cun ;

Wen, Wanqing ;

Cawthon, Richard ;

Chatterjee, Nilanjan ;

Hu, Wei ;

Caporaso, Neil E. ;

Park, Jae Yong ;

Chen, Chien-Jen ;

Kim, Yeul Hong ;

Kim, Young Tae ;

Landi, Maria Teresa ;

Shen, Hongbing ;

Lawrence, Charles ;

Burdett, Laurie ;

Yeager, Meredith ;

Chang, I-Shou ;

Mitsudomi, Tetsuya ;

Kim, Hee Nam ;

Chang, Gee-Chen ;

Bassig, Bryan A. ;

Tucker, Margaret ;

Wei, Fusheng ;

Yin, Zhihua ;

An, She-Juan ;

Qian, Biyun ;

Lee, Victor Ho Fun ;

Lu, Daru ;

Liu, Jianjun ;

Jeon, Hyo-Sung ;

Hsiao, Chin-Fu ;

Sung, Jae Sook ;

Kim, Jin Hee ;

Gao, Yu-Tang ;

Tsai, Ying-Huang ;

Jung, Yoo Jin ;

Guo, Huan ;

Hu, Zhibin ;

Hutchinson, Amy ;

Wang, Wen-Chang .

INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (02) :311-319

[7] Telomere Length in White Blood Cell DNA and Lung Cancer: A Pooled Analysis of Three Prospective Cohorts [J].

Seow, Wei Jie ;

Cawthon, Richard M. ;

Purdue, Mark P. ;

Hu, Wei ;

Gao, Yu-Tang ;

Huang, Wen-Yi ;

Weinstein, Stephanie J. ;

Ji, Bu-Tian ;

Virtamo, Jarmo ;

Hosgood, H. Dean, III ;

Bassig, Bryan A. ;

Shu, Xiao-Ou ;

Cai, Qiuyin ;

Xiang, Yong-Bing ;

Min, Shen ;

Chow, Wong-Ho ;

Berndt, Sonja I. ;

Kim, Christopher ;

Lim, Unhee ;

Albanes, Demetrius ;

Caporaso, Neil E. ;

Chanock, Stephen ;

Zheng, Wei ;

Rothman, Nathaniel ;

Lan, Qing .

CANCER RESEARCH, 2014, 74 (15) :4090-4098

[8] UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age [J].

Sudlow, Cathie ;

Gallacher, John ;

Allen, Naomi ;

Beral, Valerie ;

Burton, Paul ;

Danesh, John ;

Downey, Paul ;

Elliott, Paul ;

Green, Jane ;

Landray, Martin ;

Liu, Bette ;

Matthews, Paul ;

Ong, Giok ;

Pell, Jill ;

Silman, Alan ;

Young, Alan ;

Sprosen, Tim ;

Peakman, Tim ;

Collins, Rory .

PLOS MEDICINE, 2015, 12 (03)

[9] Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed [J].

Taub, Margaret A. ;

Conomos, Matthew P. ;

Keener, Rebecca ;

Iyer, Kruthika R. ;

Weinstock, Joshua S. ;

Yanek, Lisa R. ;

Lane, John ;

Miller-Fleming, Tyne W. ;

Brody, Jennifer A. ;

Raffield, Laura M. ;

McHugh, Caitlin P. ;

Jain, Deepti ;

Gogarten, Stephanie M. ;

Laurie, Cecelia A. ;

Keramati, Ali ;

Arvanitis, Marios ;

Smith, Albert, V ;

Heavner, Benjamin ;

Barwick, Lucas ;

Becker, Lewis C. ;

Bis, Joshua C. ;

Blangero, John ;

Bleecker, Eugene R. ;

Burchard, Esteban G. ;

Celedon, Juan C. ;

Chang, Yen Pei C. ;

Custer, Brian ;

Darbar, Dawood ;

de las Fuentes, Lisa ;

DeMeo, Dawn L. ;

Freedman, Barry, I ;

Garrett, Melanie E. ;

Gladwin, Mark T. ;

Heckbert, Susan R. ;

Hidalgo, Bertha A. ;

Irvin, Marguerite R. ;

Islam, Talat ;

Johnson, W. Craig ;

Kaab, Stefan ;

Launer, Lenore ;

Lee, Jiwon ;

Liu, Simin ;

Moscati, Arden ;

North, Kari E. ;

Peyser, Patricia A. ;

Rafaels, Nicholas ;

Seidman, Christine ;

Weeks, Daniel E. ;

Wen, Fayun ;

Wheeler, Marsha M. .

CELL GENOMICS, 2022, 2 (01)

[10] Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study [J].

Yuan, Jian-Min ;

Beckman, Kenneth B. ;

Wang, Renwei ;

Bull, Caroline ;

Adams-Haduch, Jennifer ;

Huang, Joyce Y. ;

Jin, Aizhen ;

Opresko, Patricia ;

Newman, Anne B. ;

Zheng, Yun-Ling ;

Fenech, Michael ;

Koh, Woon-Puay .

INTERNATIONAL JOURNAL OF CANCER, 2018, 142 (11) :2234-2243

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