EFFECT OF X-RAYS ON LIVER METABOLISM

The experiment was carried out on 20 heads of white rats divided into 3 groups of 5 heads each. The 1st group included intact rats. Experimental animals of the 2nd group were irradiated with X-rays. In white rats belonging to group 3, liver enzymes were detected in the blood 10 days after the cessation of X-ray irradiation. Experimental animals were irradiated with X-rays using the RUM-17 apparatus. The results of our studies showed that the concentrations of liver enzymes in the blood of white rats exposed to X-ray irradiation were elevated and differed from the norm. Thus, the concentration of aspartate aminotransferase in the blood was 27 % compared to the intact state (P<0.05), alanine aminotransferase -30 % (P<0.05), glutamine transferase increased by 17 %, lactate dehydrogenase - by 31 % (P<0.05). The concentration of creatine phosphokinase in the blood, which is the main index of the reparative process, was increased by 52 % above the level in the intact state (P<0.001). The synthesis of liver enzymes in the blood of experimental animals irradiated with X-rays was disrupted and led to changes corresponding to hepatitis. Free lipid peroxidation also increased in the liver tissues of experimental animals. The content of hydrogen peroxide, diene conjugate and malondialdehyde in the blood increased by 87.5 %, 61.5 % and 158 % compared to the intact state, respectively. In the homogenate, the average concentrations of surface - located SH-groups, internal protein SH-groups, catalase and total antioxidant decreased to the intact state.