Candida auris Genetics and Emergence

被引：70

作者：

Chowdhary, Anuradha ^{[1
,2
]}

Jain, Kusum ^{[1
]}

Chauhan, Neeraj ^{[3
]}

机构：

[1] Univ Delhi, Vallabhbhai Patel Chest Inst, Dept Microbiol, Med Mycol Unit, Delhi, India

[2] Univ Delhi, Vallabhbhai Patel Chest Inst, Natl Reference Lab Antimicrobial Resistance Funga, Delhi, India

[3] Hackensack Meridian Hlth, Ctr Discovery & Innovat, Nutley, NJ USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 2023年 / 77卷

基金：

美国国家卫生研究院;

关键词：

antifungal drug resistance; azoles; amphotericin B; echinocandin; cell wall; MAP kinase signaling;

D O I：

10.1146/annurev-micro-032521-015858

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Candida auris is a multidrug-resistant fungal pathogen that presents a serious threat to global human health. Since the first reported case in 2009 in Japan, C. auris infections have been reported in more than 40 countries, with mortality rates between 30% and 60%. In addition, C. auris has the potential to cause outbreaks in health care settings, especially in nursing homes for elderly patients, owing to its efficient transmission via skin-toskin contact. Most importantly, C. auris is the first fungal pathogen to show pronounced and sometimes untreatable clinical drug resistance to all known antifungal classes, including azoles, amphotericin B, and echinocandins. In this review, we explore the causes of the rapid spread of C. auris. We also highlight its genome organization and drug resistance mechanisms and propose future research directions that should be undertaken to curb the spread of this multidrug-resistant pathogen.

引用

页码：583 / 602

页数：20