The role of m6A RNA methylation in autoimmune diseases: Novel therapeutic opportunities

被引：9
作者：
Shan, Yunan [1 ,2 ,3 ]
Chen, Wei [4 ]
Li, Yanbin [2 ,3 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan 250013, Shandong, Peoples R China
[2] Shandong First Med Univ, Affiliated Hosp 1, Dept Neurol, Jinan 250013, Shandong, Peoples R China
[3] Shandong Prov Qianfoshan Hosp, Shandong Inst Neuroimmunol, Shandong Key Lab Rheumat Dis & Translat Med, Jinan 250013, Shandong, Peoples R China
[4] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Dept Gastroenterol, Shanghai 200233, Peoples R China
来源：
GENES & DISEASES | 2024年 / 11卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Adaptive immunity; Autoimmune diseases; Innate immunity; Immune response; m6A RNA methylation; MESSENGER-RNA; NUCLEAR-RNA; M(6)A METHYLTRANSFERASE; FAT MASS; B-CELLS; N-6-METHYLADENOSINE; DEMETHYLASE; BINDING; PROTEIN; ALKBH5;
D O I：
10.1016/j.gendis.2023.02.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
N6-methyladenosine (m6A) modifications, as one of the most common forms of in-ternal RNA chemical modifications in eukaryotic cells, have gained increasing attention in recent years. The m6A RNA modifications exert various crucial roles in various biological pro-cesses, such as embryonic development, neurogenesis, circadian rhythms, and tumorigenesis. Recent advances have highlighted that m6A RNA modification plays an important role in im-mune response, especially in the initiation and progression of autoimmune diseases. In this re-view, we summarized the regulatory mechanisms of m6A methylation and its biological functions in the immune system and mainly focused on recent progress in research on the po-tential role of m6A RNA methylation in the pathogenesis of autoimmune diseases, thus providing possible biomarkers and potential targets for the prevention and treatment of auto -immune diseases.
引用
收藏
页码：252 / 267
页数：16
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