Cystic Hypersecretory Carcinoma of the Breast: A Rare Case Report with Review of Literature and Emphasis on Differential Diagnosis

被引:0
作者
Dhandapani, Karthik [1 ]
Shah, Ashini [1 ,2 ]
Kapoor, Shilpa [1 ]
Gandhi, Jahnavi [1 ]
Thayakaran, Immanuel Paul [1 ]
Trivedi, Priti [1 ]
机构
[1] Gujarat Canc Res Inst, Dept Oncopathol, Ahmadabad, Gujarat, India
[2] Gujarat Canc Res Inst, Ahmadabad 380016, Gujarat, India
关键词
cystic hypersecretory carcinoma; cystic hypersecretory hyperplasia; breast carcinoma; DUCT CARCINOMA; VARIANT;
D O I
10.1055/s-0043-1768629
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cystic hypersecretory carcinoma (CHC) is a rare subset of in-situ breast carcinoma with or without associated invasive carcinoma. It is part of a spectrum of cystic hypersecretory lesions that includes cystic hypersecretory hyperplasia (CHH), CHH with atypia, CHC in situ, and CHC with invasion. Only 20 cases of CHC with invasion have been reported so far. A 60-year-old female presented with a palpable right breast mass. A core needle biopsy was carried out, which was reported as invasive breast carcinoma with areas of ductal carcinoma in situ (DCIS). Modified radical mastectomy was done post-neo-adjuvant chemotherapy; On microscopy, dilated cystic spaces filled with eosinophilic secretions (thyroid colloid-like), lining neoplastic cells with variable degrees of proliferation and atypia were seen. There were multiple foci of invasion; both skin invasion and axillary lymph node metastasis were present. Immunohistochemistry (IHC) was done with relevant markers; correlating all these findings, a diagnosis of CHC with invasion was made. CHC is a distinct form of DCIS with or without associated invasion. Awareness of this entity is required to rule out other differential diagnoses and to avoid misinterpretation. Little is known about the IHC profile, biological behavior, prognosis, and molecular profile of CHC due to its rarity.
引用
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页码:297 / 302
页数:6
相关论文
共 12 条
[1]   Cystic Hypersecretory (In Situ) Carcinoma of the Breast A Clinicopathologic and Immunohistochemical Characterization of 10 Cases With Clinical Follow-up [J].
D'Alfonso, Timothy M. ;
Ginter, Paula S. ;
Liu, Yi-Fang ;
Shin, Sandra J. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2014, 38 (01) :45-53
[2]  
GUERRY P, 1988, CANCER-AM CANCER SOC, V61, P1611, DOI 10.1002/1097-0142(19880415)61:8<1611::AID-CNCR2820610819>3.0.CO
[3]  
2-O
[4]   Cystic hypersecretory duct carcinoma of the breast: Report of two cases [J].
Park, JM ;
Seo, MR .
CLINICAL RADIOLOGY, 2002, 57 (04) :312-315
[5]   CYSTIC HYPERSECRETORY DUCT CARCINOMA OF THE BREAST [J].
ROSEN, PP ;
SCOTT, M .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1984, 8 (01) :31-41
[6]   Cystic hypersecretory carcinoma: rare and poorly recognized variant of intraductal carcinoma of the breast. Report of five cases [J].
Skalova, A ;
Ryska, A ;
Kajo, K ;
Di Palma, S ;
Kinkor, Z ;
Michal, M .
HISTOPATHOLOGY, 2005, 46 (01) :43-49
[7]   Cystic hypersecretory ductal carcinoma of the breast: a rare cause of cystic breast mass [J].
Song, Sun Wha ;
Whang, In Yong ;
Chang, Eun Deok .
JAPANESE JOURNAL OF RADIOLOGY, 2011, 29 (09) :660-662
[8]   Invasive cystic hypersecretory carcinoma of the breast: a rare variant of breast cancer: a case report and review of the literature [J].
Sun, Jie ;
Wang, Xing ;
Wang, Cuifang .
BMC CANCER, 2019, 19 (1)
[9]  
Syed Hoda, 2020, ROSENS BREAST PATHOL
[10]   Comparison of core needle biopsy (CNB) and surgical specimens for accurate preoperative evaluation of ER, PgR and HER2 status of breast cancer patients [J].
Tamaki, Kentaro ;
Sasano, Hironobu ;
Ishida, Takanori ;
Miyashita, Minoru ;
Takeda, Motohiro ;
Amari, Masakazu ;
Tamaki, Nobumitsu ;
Ohuchi, Noriaki .
CANCER SCIENCE, 2010, 101 (09) :2074-2079