Immunomodulatory role of decidual prolactin on the human fetal membranes and placenta

被引：10

作者：

Flores-Espinosa, Pilar ^{[1
]}

Mendez, Isabel ^{[2
]}

Irles, Claudine ^{[3
]}

Olmos-Ortiz, Andrea ^{[1
]}

Helguera-Repetto, Cecilia ^{[1
]}

Mancilla-Herrera, Ismael ^{[4
]}

Ortuno-Sahagun, Daniel ^{[5
]}

Goffin, Vincent ^{[6
]}

Zaga-Clavellina, Veronica ^{[1
]}

机构：

[1] Inst Nacl Perinatol Isidro Espinosa Reyes, Dept Inmunobioquim, Mexico City, Mexico

[2] Univ Nacl Autonoma Mexico, Dept Neurobiol Celular & Mol, Inst Neurobiol, Campus UNAM Juriquilla, Juriquilla, Queretaro, Mexico

[3] Univ Sorbonne Paris Nord, Inst Natl Sante & Rech Med INSERM U978, Unite Format & Rech UFR Sante Med & Biol Humaine, Bobigny, France

[4] Inst Nacl Perinatol Isidro Espinosa Reyes, Dept Infectol & Inmunol, Mexico City, Mexico

[5] Univ Guadalajara, Lab Neuroinmunobiol Mol, Inst Invest Ciencias Biomed, Guadalajara, Mexico

[6] Univ Paris Cite, Inst Natl Sante & Rech Med INSERM, Inst Necker Enfants Malad, Unite Mixte Rech UMR S1151,CNRS,Unite Mixte Rech, Paris, France

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

immune privilege; decidual prolactin; pregnancy; maternal-fetal interface; fetal membranes; placenta; preterm labor; innate immunity; ENDOTHELIAL GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; MACROPHAGES IN-VITRO; AMNIOTIC-FLUID; DEVELOPMENTAL EXPRESSION; FETOMATERNAL INTERFACE; EXTRACELLULAR-MATRIX; TRANSCRIPTION FACTOR; PRETERM LABOR; RAT DECIDUA;

D O I：

10.3389/fimmu.2023.1212736

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The close interaction between fetal and maternal cells during pregnancy requires multiple immune-endocrine mechanisms to provide the fetus with a tolerogenic environment and protection against any infectious challenge. The fetal membranes and placenta create a hyperprolactinemic milieu in which prolactin (PRL) synthesized by the maternal decidua is transported through the amnion-chorion and accumulated into the amniotic cavity, where the fetus is bedded in high concentrations during pregnancy. PRL is a pleiotropic immune-neuroendocrine hormone with multiple immunomodulatory functions mainly related to reproduction. However, the biological role of PRL at the maternal-fetal interface has yet to be fully elucidated. In this review, we have summarized the current information on the multiple effects of PRL, focusing on its immunological effects and biological significance for the immune privilege of the maternal-fetal interface.

引用

页数：11

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