Ursolic Acid against Prostate and Urogenital Cancers: A Review of In Vitro and In Vivo Studies

被引:15
|
作者
Kornel, Amanda [1 ]
Nadile, Matteo [1 ]
Retsidou, Maria Ilektra [2 ]
Sakellakis, Minas [3 ]
Gioti, Katerina [4 ]
Beloukas, Apostolos [4 ,5 ]
Sze, Newman Siu Kwan [1 ]
Klentrou, Panagiota [2 ,6 ]
Tsiani, Evangelia [1 ,6 ]
机构
[1] Brock Univ, Fac Appl Hlth Sci, Dept Hlth Sci, St Catharines, ON L2S 3A1, Canada
[2] Brock Univ, Fac Appl Hlth Sci, Dept Kinesiol, St Catharines, ON L2S 3A1, Canada
[3] Metropolitan Hosp, Dept Med Oncol, Athens 18547, Greece
[4] Univ West Attica, Sch Hlth Sci, Dept Biomed Sci, Athens 12243, Greece
[5] Univ West Attica, Natl AIDS Reference Ctr Southern Greece, Sch Publ Hlth, Athens 11521, Greece
[6] Brock Univ, Ctr Bone & Muscle Hlth, Appl Hlth Sci, St Catharines, ON L2S 3A1, Canada
关键词
ursolic acid; prostate; urogenital; cancer; survival; apoptosis; proliferation; signaling cascades; ANDROGEN DEPRIVATION THERAPY; INDUCED APOPTOSIS; OLEANOLIC ACID; CORNI FRUCTUS; TUMOR; INHIBITION; PATHWAY; ACTIVATION; BLADDER; CELLS;
D O I
10.3390/ijms24087414
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Prostate cancer is the second most diagnosed form of cancer in men worldwide and accounted for roughly 1.3 million cases and 359,000 deaths globally in 2018, despite all the available treatment strategies including surgery, radiotherapy, and chemotherapy. Finding novel approaches to prevent and treat prostate and other urogenital cancers effectively is of major importance. Chemicals derived from plants, such as docetaxel and paclitaxel, have been used in cancer treatment, and in recent years, research interest has focused on finding other plant-derived chemicals that can be used in the fight against cancer. Ursolic acid, found in high concentrations in cranberries, is a pentacyclic triterpenoid compound demonstrated to have anti-inflammatory, antioxidant, and anticancer properties. In the present review, we summarize the research studies examining the effects of ursolic acid and its derivatives against prostate and other urogenital cancers. Collectively, the existing data indicate that ursolic acid inhibits human prostate, renal, bladder, and testicular cancer cell proliferation and induces apoptosis. A limited number of studies have shown significant reduction in tumor volume in animals xenografted with human prostate cancer cells and treated with ursolic acid. More animal studies and human clinical studies are required to examine the potential of ursolic acid to inhibit prostate and other urogenital cancers in vivo.
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页数:19
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