Type 2 vomeronasal receptor-A4 subfamily: Potential predator sensors in mice

被引:2
作者
Rocha, Andrea [1 ]
Nguyen, Quynh Anh Thi [1 ]
Haga-Yamanaka, Sachiko [1 ,2 ,3 ]
机构
[1] Univ Calif Riverside, Neurosci Grad Program, Riverside, CA USA
[2] Univ Calif Riverside, Dept Mol Cell & Syst Biol, Riverside, CA USA
[3] Univ Calif Riverside, Dept Mol Cell & Syst Biol, 900 Univ Ave, Riverside, CA 92521 USA
基金
美国国家卫生研究院;
关键词
organism; mammal; mouse; rat; process; genetics; signaling; tissue; olfactory organ; vomeronasal organ; PUTATIVE PHEROMONE RECEPTORS; ACCESSORY OLFACTORY-BULB; CLASS-I PEPTIDES; SEX-DISCRIMINATION; CHEMOSENSORY SIGNALS; AXONAL PROJECTIONS; MULTIGENE FAMILY; EVOLUTION; ORGAN; AGGRESSION;
D O I
10.1002/dvg.23597
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Sensory signals detected by olfactory sensory organs are critical regulators of animal behavior. An accessory olfactory organ, the vomeronasal organ, detects cues from other animals and plays a pivotal role in intra- and inter-species interactions in mice. However, how ethologically relevant cues control mouse behavior through approximately 350 vomeronasal sensory receptor proteins largely remains elusive. The type 2 vomeronasal receptor-A4 (V2R-A4) subfamily members have been repeatedly detected from vomeronasal sensory neurons responsive to predator cues, suggesting a potential role of this receptor subfamily as a sensor for predators. This review focuses on this intriguing subfamily, delving into its receptor functions and genetic characteristics.
引用
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页数:8
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