Anticancer effect and laser photostability of ternary graphene oxide/chitosan/silver nanocomposites on various cancer cell lines

被引：12
|
作者：
Ramadan, Marwa A. [1 ]
Sharaky, Marwa [2 ,3 ]
Gad, Sara [3 ]
Ahmed, Hoda A. [4 ]
Jaremko, Mariusz [5 ]
Emwas, Abdul-Hamid [6 ]
Faid, Amna H. [7 ]
机构：
[1] Cairo Univ CU, Natl Inst Laser Enhanced Sci NILES, Dept Laser Applicat Metrol Photochem & Agr, Giza, Egypt
[2] Cairo Univ, Natl Canc Inst, Canc Biol Dept, Pharmacol Unit, Cairo, Egypt
[3] City Sci Res & Technol Applicat SRTA City, Alexandria, Egypt
[4] Cairo Univ, Fac Sci, Dept Chem, Cairo 12613, Egypt
[5] King Abdullah Univ Sci & Technol KAUST, Biol & Environm Sci & Engn Div BESE, Thuwal 239556900, Saudi Arabia
[6] King Abdullah Univ Sci & Technol, Core Labs, Thuwal 239556900, Saudi Arabia
[7] Cairo Univ, Natl Inst Laser Enhanced Sci NILES, Dept Laser Sci & Interact, Giza, Egypt
来源：
NANOMEDICINE | 2024年 / 19卷 / 08期
关键词：
antitumor; breast tumor; colon cancer; graphene oxide/chitosan nanocomposite; graphene oxide/chitosan/silver nanocomposite; hypopharyngeal cell lines; laser photostability; lung cancer; SILVER NANOPARTICLES; OXIDE NANOHYBRIDS; CHITOSAN; CYTOTOXICITY; NANOCRYSTALS;
D O I：
10.2217/nnm-2023-0264
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aims: The development of nanocomposites (NCs) of antitumor activity provides a new paradigm for fighting cancer. Here, a novel NC of green synthetic silver nanoparticles (AgNPs), graphene oxide (GO) and chitosan (Cs) NPs was developed. Materials & methods: The prepared GO/Cs/Ag NCs were analyzed using various techniques. Cytotoxicity of the NCs was evaluated against different cancer cell lines by Sulforhodamine B (SRB) assay. Results: GO/Cs/Ag NCs are novel and highly stable. UV-Vis showed two peaks at 227 and 469 nm, indicating the decoration of AgNPs on the surface of GO/Cs NPs. All tested cell lines were affected by GO/Cs NPs and GO/Cs/Ag NCs. Conclusion: The results indicate that GO/Cs/Ag NCs were present on tested cell lines and are a promising candidate for cancer therapy.
引用
收藏
页码：709 / 722
页数：14
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