Gut microbiota and intestinal immunity-A crosstalk in irritable bowel syndrome

被引：17

作者：

Chen, Yuxuan ^{[1
]}

Feng, Shuyan ^{[2
]}

Li, Ying ^{[2
]}

Zhang, Chi ^{[3
]}

Chao, Guanqun ^{[4
,6
]}

Zhang, Shuo ^{[1
,5
,7
]}

机构：

[1] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China

[2] Zhejiang Chinese Med Univ, Clin Med Coll 1, Hangzhou, Peoples R China

[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Hangzhou, Peoples R China

[4] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Gen Practice, Hangzhou, Peoples R China

[5] Zhejiang Chinese Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Hangzhou, Peoples R China

[6] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Gen Practice, Hangzhou 310018, Peoples R China

[7] Zhejiang Chinese Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Hangzhou 310005, Peoples R China

来源：

IMMUNOLOGY | 2024年 / 172卷 / 01期

基金：

中国国家自然科学基金;

关键词：

gut microbiota; intestinal immunity; intestinal mucosa; irritable bowel syndrome; RAT MODEL; VISCERAL HYPERSENSITIVITY; MAST-CELLS; BRAIN; SYMPTOMS; DIARRHEA; NEURONS; MUCOSA; PREDOMINANT; PREVALENCE;

D O I：

10.1111/imm.13749

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Irritable bowel syndrome (IBS), one of the most prevalent functional gastrointestinal disorders, is characterized by recurrent abdominal pain and abnormal defecation habits, resulting in a severe healthcare burden worldwide. The pathophysiological mechanisms of IBS are multi-factorially involved, including food antigens, visceral hypersensitivity reactions, and the brain-gut axis. Numerous studies have found that gut microbiota and intestinal mucosal immunity play an important role in the development of IBS in crosstalk with multiple mechanisms. Therefore, based on existing evidence, this paper elaborates that the damage and activation of intestinal mucosal immunity and the disturbance of gut microbiota are closely related to the progression of IBS. Combined with the application prospect, it also provides references for further in-depth exploration and clinical practice. Gut microbiota dysbiosis and intestinal mucosal immune imbalance participate in the development of irritable bowel syndrome.image

引用

页码：1 / 20

页数：20

共 168 条

[1] Immune activation in irritable bowel syndrome: what is the evidence? [J].

Aguilera-Lizarraga, Javier ;

Hussein, Hind ;

Boeckxstaens, Guy E. .

NATURE REVIEWS IMMUNOLOGY, 2022, 22 (11) :674-686

[2] Local immune response to food antigens drives meal-induced abdominal pain [J].

Aguilera-Lizarraga, Javier ;

Florens, Morgane, V ;

Viola, Maria Francesca ;

Jain, Piyush ;

Decraecker, Lisse ;

Appeltans, Iris ;

Cuende-Estevez, Maria ;

Fabre, Naomi ;

Van Beek, Kim ;

Perna, Eluisa ;

Balemans, Dafne ;

Stakenborg, Nathalie ;

Theofanous, Stavroula ;

Bosmans, Goele ;

Mondelaers, Stephanie U. ;

Matteoli, Gianluca ;

Martinez, Sales Ibiza ;

Lopez-Lopez, Cintya ;

Jaramillo-Polanco, Josue ;

Talavera, Karel ;

Alpizar, Yeranddy A. ;

Feyerabend, Thorsten B. ;

Rodewald, Hans-Reimer ;

Farre, Ricard ;

Redegeld, Frank A. ;

Si, Jiyeon ;

Raes, Jeroen ;

Breynaert, Christine ;

Schrijvers, Rik ;

Bosteels, Cedric ;

Lambrecht, Bart N. ;

Boyd, Scott D. ;

Hoh, Ramona A. ;

Cabooter, Deirdre ;

Nelis, Maxim ;

Augustijns, Patrick ;

Hendrix, Sven ;

Strid, Jessica ;

Bisschops, Raf ;

Reed, David E. ;

Vanner, Stephen J. ;

Denadai-Souza, Alexandre ;

Wouters, Mira M. ;

Boeckxstaens, Guy E. .

NATURE, 2021, 590 (7844) :151-+

[3] Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation [J].

Agus, Allison ;

Denizot, Jeremy ;

Thevenot, Jonathan ;

Martinez-Medina, Margarita ;

Massier, Sebastien ;

Sauvanet, Pierre ;

Bernalier-Donadille, Annick ;

Denis, Sylvain ;

Hofman, Paul ;

Bonnet, Richard ;

Billard, Elisabeth ;

Barnich, Nicolas .

SCIENTIFIC REPORTS, 2016, 6

[4] Gut-organ axis: a microbial outreach and networking [J].

Ahlawat, S. ;

Asha ;

Sharma, K. K. .

LETTERS IN APPLIED MICROBIOLOGY, 2021, 72 (06) :636-668

[5] Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis [J].

Albert-Bayo, Merce ;

Paracuellos, Irene ;

Gonzalez-Castro, Ana M. ;

Rodriguez-Urrutia, Amanda ;

Rodriguez-Lagunas, Maria J. ;

Alonso-Cotoner, Carmen ;

Santos, Javier ;

Vicario, Maria .

CELLS, 2019, 8 (02)

[6] The Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target [J].

An, Jia ;

Liu, Yuqing ;

Wang, Yiqi ;

Fan, Ru ;

Hu, Xiaorong ;

Zhang, Fen ;

Yang, Jinhua ;

Chen, Junwei .

FRONTIERS IN IMMUNOLOGY, 2022, 13

[7] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[8] Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome [J].

Atkinson, W ;

Lockhart, S ;

Whorwell, PJ ;

Keevil, B ;

Houghton, LA .

GASTROENTEROLOGY, 2006, 130 (01) :34-43

[9] Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M) [J].

Awad, Karem ;

Barmeyer, Christian ;

Bojarski, Christian ;

Nagel, Oliver ;

Lee, In-Fah M. ;

Schweiger, Michal R. ;

Schulzke, Joerg-Dieter ;

Buecker, Roland .

CELLS, 2023, 12 (02)

[10] Irritable Bowel Syndrome, Depression, and Neurodegeneration: A Bidirectional Communication from Gut to Brain [J].

Aziz, Muhammad Nazirul Mubin ;

Kumar, Jaya ;

Muhammad Nawawi, Khairul Najmi ;

Raja Ali, Raja Affendi ;

Mokhtar, Norfilza M. .

NUTRIENTS, 2021, 13 (09)

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