Outcomes and prognostic factors of patients with Extranodal NK T cell lymphoma (ENKTL)

被引：0

作者：

Rajendra, Akhil ^{[1
]}

Sengar, Manju ^{[2
]}

Bonda, V. N. Avinash ^{[3
]}

Jain, Hasmukh ^{[2
]}

Nayak, Lingaraj ^{[2
]}

Thorat, Jayashree ^{[2
]}

Shet, Tanuja ^{[4
]}

Epari, Sridhar ^{[4
]}

Laskar, Siddharth ^{[2
]}

Aggarwal, Archi ^{[5
]}

Rangarajan, V. ^{[4
]}

Gujral, Sumeet ^{[4
]}

Bagal, Bhausaheb ^{[2
]}

Kakoti, Sangeeta ^{[2
]}

Salvi, Omkar ^{[6
]}

机构：

[1] Canc Inst, Dept Med oncol, WIA, Chennai, Tamil Nadu, India

[2] Homi Bhabha Natl Inst HBNI, Tata Mem Ctr, Dept Med Oncol, Mumbai, India

[3] AIG Hosp, Inst Oncol, Med Oncol, Hyderabad, India

[4] Homi Bhabha Natl Inst HBNI, Tata Mem Ctr, Dept Pathol, Mumbai, India

[5] Homi Bhabha Natl Inst HBNI, Tata Mem Ctr, Dept Nucl Med, Mumbai, India

[6] Homi Bhabha Natl Inst HBNI, Tata Mem Ctr, Clin Res Secretariat, Mumbai, India

来源：

LEUKEMIA & LYMPHOMA | 2023年 / 64卷 / 12期

关键词：

Real world outcomes Extranodal NK T cell lymphoma; L-asparaginase; KILLER (NK)/T-CELL LYMPHOMA; WORLD-HEALTH-ORGANIZATION; NASAL-TYPE; L-ASPARAGINASE; CONCURRENT CHEMORADIOTHERAPY; RADIATION-THERAPY; PHASE-II; STAGE IE; CLINICAL-FEATURES; CHEMOTHERAPY;

D O I：

10.1080/10428194.2023.2244101

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The staging, prognostication, and treatment of ENKTL has evolved over the years with better understanding of the disease biology. There is significant heterogeneity in the treatment followed across the world. Literature from India have been few with small number of patients. We studied the outcomes and prognostic factors of patients with ENKTL treated between May 2010 and December 2021 at our center. A total of 78 patients diagnosed with ENKTL were treated at our center. L-asparaginase based chemotherapy was administered in 84% of the patients. Close to 2/3rd patients received SMILE chemotherapy. After a median follow-up of 30 months (18.5-41.4 months), the median relapse free survival and overall survival for the overall population was 45 months (12-118 months) and 45 months (14-118 months) respectively. By multivariate analysis, PINK score of 2-4, non-receipt of RT and non-achievement of CR were associated with poor survival.

引用

页码：1914 / 1926

页数：13

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