Potential Application of the Plant-Derived Essential Oils for Atherosclerosis Treatment: Molecular Mechanisms and Therapeutic Potential

被引：2
作者：
Dabravolski, Siarhei A. [1 ]
Sukhorukov, Vasily N. [2 ]
Melnichenko, Alexandra A. [2 ]
Khotina, Victoria A. [2 ]
Orekhov, Alexander N. [2 ]
机构：
[1] Braude Acad Coll Engn, Dept Biotechnol Engn, POB 78,Snunit 51, IL-2161002 Karmiel, Israel
[2] Inst Gen Pathol & Pathophysiol, 8 Baltiyskaya St, Moscow 125315, Russia
来源：
MOLECULES | 2023年 / 28卷 / 15期
关键词：
essential oils; atherosclerosis; inflammation; oxidative stress; endothelial dysfunction; CARDIOVASCULAR-DISEASES; CONTAINING MOUTHWASH; IN-VITRO; INJURY; CONSTITUENTS; GINGIVITIS; MICE; RISK;
D O I：
10.3390/molecules28155673
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Essential oils (EOs) are complex secondary metabolites identified in many plant species. Plant-derived EOs have been widely used in traditional medicine for centuries for their health-beneficial effects. Some EOs and their active ingredients have been reported to improve the cardiovascular system, in particular to provide an anti-atherosclerotic effect. The objective of this review is to highlight the recent research investigating the anti-inflammatory, anti-oxidative and lipid-lowering properties of plant-derived EOs and discuss their mechanisms of action. Also, recent clinical trials exploring anti-inflammatory and anti-oxidative activities of EOs are discussed. Future research on EOs has the potential to identify new bioactive compounds and invent new effective agents for treatment of atherosclerosis and related diseases such as diabetes, metabolic syndrome and obesity.
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页数：20
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共 103 条
  • [71] Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease New Insights From Epidemiology, Genetics, and Biology
    Nordestgaard, Borge G.
    [J]. CIRCULATION RESEARCH, 2016, 118 (04) : 547 - 563
  • [72] Immune-mediated mechanisms of atherosclerosis and implications for the clinic
    Nus, Meritxell
    Mallat, Ziad
    [J]. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2016, 12 (11) : 1217 - 1237
  • [73] Anti-inflammatory effect of lavender (Lavandula angustifolia Mill.) essential oil prepared during different plant phenophases on THP-1 macrophages
    Pandur, Edina
    Balatinacz, Alex
    Micalizzi, Giuseppe
    Mondello, Luigi
    Horvath, Adrienn
    Sipos, Katalin
    Horvath, Gyorgyi
    [J]. BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2021, 21 (01)
  • [74] Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease
    Pasterkamp, Gerard
    den Ruijter, Hester M.
    Libby, Peter
    [J]. NATURE REVIEWS CARDIOLOGY, 2017, 14 (01) : 21 - 29
  • [75] Role of Oxidative Stress in the Pathogenesis of Atherothrombotic Diseases
    Petrucci, Giovanna
    Rizzi, Alessandro
    Hatem, Duaa
    Tosti, Giulia
    Rocca, Bianca
    Pitocco, Dario
    [J]. ANTIOXIDANTS, 2022, 11 (07)
  • [76] Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice:: Mutations in Tlr4 gene
    Poltorak, A
    He, XL
    Smirnova, I
    Liu, MY
    Van Huffel, C
    Du, X
    Birdwell, D
    Alejos, E
    Silva, M
    Galanos, C
    Freudenberg, M
    Ricciardi-Castagnoli, P
    Layton, B
    Beutler, B
    [J]. SCIENCE, 1998, 282 (5396) : 2085 - 2088
  • [77] Anti-Inflammatory Therapy for Atherosclerosis: Focusing on Cytokines
    Poznyak, Anastasia V.
    Bharadwaj, Dwaipayan
    Prasad, Gauri
    Grechko, Andrey V.
    Sazonova, Margarita A.
    Orekhov, Alexander N.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (13)
  • [78] Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis
    Poznyak, Anastasia V.
    Nikiforov, Nikita G.
    Markin, Alexander M.
    Kashirskikh, Dmitry A.
    Myasoedova, Veronika A.
    Gerasimova, Elena V.
    Orekhov, Alexander N.
    [J]. FRONTIERS IN PHARMACOLOGY, 2021, 11
  • [79] Pingyin rose essential oil alleviates LPS-Induced inflammation in RAW 264.7 cells via the NF-κB pathway: an integrated in vitro and network pharmacology analysis
    Raka, Rifat Nowshin
    Ding Zhiqian
    Yuan Yue
    Qiao Luchang
    Suyeon, Park
    Xiao Junsong
    Wu Hua
    [J]. BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2022, 22 (01)
  • [80] An inflammation classification system using cytokine parameters
    Roe, Kevin
    [J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2021, 93 (02)
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