Potential Application of the Plant-Derived Essential Oils for Atherosclerosis Treatment: Molecular Mechanisms and Therapeutic Potential

被引：2
作者：
Dabravolski, Siarhei A. [1 ]
Sukhorukov, Vasily N. [2 ]
Melnichenko, Alexandra A. [2 ]
Khotina, Victoria A. [2 ]
Orekhov, Alexander N. [2 ]
机构：
[1] Braude Acad Coll Engn, Dept Biotechnol Engn, POB 78,Snunit 51, IL-2161002 Karmiel, Israel
[2] Inst Gen Pathol & Pathophysiol, 8 Baltiyskaya St, Moscow 125315, Russia
来源：
MOLECULES | 2023年 / 28卷 / 15期
关键词：
essential oils; atherosclerosis; inflammation; oxidative stress; endothelial dysfunction; CARDIOVASCULAR-DISEASES; CONTAINING MOUTHWASH; IN-VITRO; INJURY; CONSTITUENTS; GINGIVITIS; MICE; RISK;
D O I：
10.3390/molecules28155673
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Essential oils (EOs) are complex secondary metabolites identified in many plant species. Plant-derived EOs have been widely used in traditional medicine for centuries for their health-beneficial effects. Some EOs and their active ingredients have been reported to improve the cardiovascular system, in particular to provide an anti-atherosclerotic effect. The objective of this review is to highlight the recent research investigating the anti-inflammatory, anti-oxidative and lipid-lowering properties of plant-derived EOs and discuss their mechanisms of action. Also, recent clinical trials exploring anti-inflammatory and anti-oxidative activities of EOs are discussed. Future research on EOs has the potential to identify new bioactive compounds and invent new effective agents for treatment of atherosclerosis and related diseases such as diabetes, metabolic syndrome and obesity.
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页数：20
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