Inflammation mediates the effect of adiposity and lipid metabolism indicators on the embryogenesis of PCOS women undergoing in vitro fertilization/intracytoplasmic sperm injection

被引：3

作者：

Jiang, Huahua ^{[1
,2
,3
,4
]}

Chen, Lixue ^{[1
,2
,3
,4
]}

Tian, Tian ^{[1
,2
,3
,4
]}

Shi, Huifeng ^{[2
,5
,6
]}

Huang, Ning ^{[1
,2
,3
,4
]}

Chi, Hongbin ^{[1
,2
,3
,4
]}

Yang, Rui ^{[1
,2
,3
,4
]}

Long, Xiaoyu ^{[1
,2
,3
,4
]}

Qiao, Jie ^{[1
,2
,3
,4
,7
,8
]}

机构：

[1] Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China

[2] Peking Univ Third Hosp, Natl Clin Res Ctr Obstet & Gynecol, Beijing, Peoples R China

[3] Peking Univ, Key Lab Assisted Reprod, Minist Educ, Beijing, Peoples R China

[4] Beijing Key Lab Reprod Endocrinol & Assisted Repro, Beijing, Peoples R China

[5] Peking Univ Third Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China

[6] Natl Ctr Healthcare Qual Management Obstet, Beijing, Peoples R China

[7] Peking Univ, Beijing Adv Innovat Ctr Genom, Beijing, Peoples R China

[8] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

PCOS; adiposity; lipid metabolism; inflammation; mediating effect; IVF; ICSI outcomes; POLYCYSTIC-OVARY-SYNDROME; BODY-MASS INDEX; DIAGNOSTIC-CRITERIA; OBESITY; CELLS; OUTCOMES; FERTILIZATION; MISCARRIAGE; INFERTILITY; EXPRESSION;

D O I：

10.3389/fendo.2023.1198602

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundPolycystic ovary syndrome (PCOS) is a complex reproductive endocrine and metabolic disease affecting women of reproductive age. The low-grade chronic inflammation in PCOS is considered to be associated with obesity and dyslipidemia. We aim to investigate the potential mediating role of white blood cell (WBC) count, a representative inflammatory marker, in the effect of adiposity and lipid metabolism indicators on IVF/ICSI outcomes in PCOS women. MethodsWe conducted a retrospective cohort study of 1,534 PCOS women who underwent their first IVF/ICSI cycles with autologous oocytes at a reproductive center from January 2018 to December 2020. The associations between PCOS women's adiposity and lipid metabolism indicators and WBC count and IVF/ICSI outcomes were examined using multivariable generalized linear models. Mediation analyses were conducted to evaluate the possible mediating role of WBC count. ResultsWe found significant dose-dependent correlations between adiposity and lipid metabolism indicators and IVF/ICSI outcomes (i.e., hormone levels on the ovulatory triggering day, oocyte development outcomes, fertilization, early embryo development outcomes, and pregnancy outcomes) (all p < 0.05), as well as between adiposity and lipid metabolism indicators and WBC count (all p < 0.001). Increasing WBC count was associated with adverse oocyte and embryonic development outcomes (all p < 0.05). Mediation analyses suggested that increasing serum TG and LDL-C levels and decreasing serum HDL-C level were significantly associated with reduced high-quality Day 3 embryo count in PCOS women, with 21.51%, 9.75%, and 14.10% mediated by WBC count, respectively (all p < 0.05). ConclusionsWe observed significant associations between lipid metabolism indicators and high-quality Day 3 embryo count in PCOS women, partially mediated by inflammation-related mechanisms, suggesting the potential intervention target for improving embryo quality in PCOS women.

引用

页数：11