Neurotrophin signalling in the human nervous system

被引：24

作者：

Ateaque, Sarah ^{[1
]}

Merkouris, Spyros ^{[1
]}

Barde, Yves-Alain ^{[1
]}

机构：

[1] Cardiff Univ, Sch Biosci, Cardiff, Wales

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2023年 / 16卷

关键词：

Neurotrophins (NTs); Trk receptors; memory; depression; neurodegeneration; blood platelets; BDNF ELISA; ACTIVITY-DEPENDENT REGULATION; EMBRYONIC STEM-CELLS; TRKB MESSENGER-RNA; VAL66MET POLYMORPHISM; BDNF GENE; SYMPATHETIC-GANGLIA; SEVERE OBESITY; GROWTH-FACTOR; BRAIN; RECEPTOR;

D O I：

10.3389/fnmol.2023.1225373

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis on their relevance to the function and dysfunction in the human nervous system. It also deals with measurements of BDNF levels and highlights recent findings from our laboratory on TrkB and TrkC signalling in human neurons. These include ligand selectivity and Trk activation by neurotrophins and non-neurotrophin ligands. The ligand-induced down-regulation and re-activation of Trk receptors is also discussed.

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页数：9

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共 96 条

[1] Proteome and functional decline as platelets age in the circulation [J].

Allan, Harriet E. ;

Hayman, Melissa A. ;

Marcone, Simone ;

Chan, Melissa, V ;

Edin, Matthew L. ;

Maffucci, Tania ;

Joshi, Abhishek ;

Menke, Laura ;

Crescente, Marilena ;

Mayr, Manuel ;

Zeldin, Darryl C. ;

Armstrong, Paul C. ;

Warner, Timothy D. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2021, 19 (12) :3095-3112

[2] DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons [J].

Andreska, Thomas ;

Luningschror, Patrick ;

Wolf, Daniel ;

McFleder, Rhonda L. ;

Ayon-Olivas, Maurilyn ;

Rattka, Marta ;

Drechsler, Christine ;

Perschin, Veronika ;

Blum, Robert ;

Aufmkolk, Sarah ;

Granado, Noelia ;

Moratalla, Rosario ;

Sauer, Markus ;

Monoranu, Camelia ;

Volkmann, Jens ;

Ip, Chi Wang ;

Stigloher, Christian ;

Sendtner, Michael .

CELL REPORTS, 2023, 42 (06)

[3] Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning [J].

Andreska, Thomas ;

Rauskolbb, Stefanie ;

Schukraft, Nina ;

Lueningschror, Patrick ;

Sasi, Manju ;

Signoret-Genest, Jeremy ;

Behringer, Marcus ;

Blum, Robert ;

Sauer, Markus ;

Tovote, Philip ;

Sendtner, Michael .

JOURNAL OF NEUROSCIENCE, 2020, 40 (33) :6289-6308

[4] Activin A directs striatal projection neuron differentiation of human pluripotent stem cells [J].

Arber, Charles ;

Precious, Sophie V. ;

Cambray, Serafi ;

Risner-Janiczek, Jessica R. ;

Kelly, Claire ;

Noakes, Zoe ;

Fjodorova, Marija ;

Heuer, Andreas ;

Ungless, Mark A. ;

Rodriguez, Tristan A. ;

Rosser, Anne E. ;

Dunnett, Stephen B. ;

Li, Meng .

DEVELOPMENT, 2015, 142 (07) :1375-1386

[5] Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC [J].

Ateaque, Sarah ;

Merkouris, Spyros ;

Wyatt, Sean ;

Allen, Nicholas D. ;

Xie, Jia ;

DiStefano, Peter S. ;

Lindsay, Ronald M. ;

Barde, Yves-Alain .

JOURNAL OF NEUROCHEMISTRY, 2022, 161 (06) :463-477

[6] Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases [J].

Azman, Khairunnuur Fairuz ;

Zakaria, Rahimah .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (12)

[7] An Agonistic TrkB mAb Causes Sustained TrkB Activation, Delays RGC Death, and Protects the Retinal Structure in Optic Nerve Axotomy and in Glaucoma [J].

Bai, Yujing ;

Xu, Jing ;

Brahimi, Fouad ;

Zhuo, Yehong ;

Sarunic, Marinko V. ;

Saragovi, H. Uri .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (09) :4722-4731

[8] BDNF Val66Met Impairs Fluoxetine-Induced Enhancement of Adult Hippocampus Plasticity [J].

Bath, Kevin G. ;

Jing, Deqiang Q. ;

Dincheva, Iva ;

Neeb, Christine C. ;

Pattwell, Siobhan S. ;

Chao, Moses V. ;

Lee, Francis S. ;

Ninan, Ipe .

NEUROPSYCHOPHARMACOLOGY, 2012, 37 (05) :1297-1304

[9] Differentiation of mouse embryonic stem cells into a defined neuronal lineage [J].

Bibel, M ;

Richter, J ;

Schrenk, K ;

Tucker, KL ;

Staiger, V ;

Korte, M ;

Goetz, M ;

Barde, YA .

NATURE NEUROSCIENCE, 2004, 7 (09) :1003-1009

[10] Multiplex quantitative assays indicate a need for re-evaluating reported small-molecule TrkB agonists [J].

Boltaev, Umed ;

Meyer, Yves ;

Tolibzoda, Farangis ;

Jacques, Teresa ;

Gassaway, Madalee ;

Xu, Qihong ;

Wagner, Florence ;

Zhang, Yan-Ling ;

Palmer, Michelle ;

Holson, Edward ;

Sames, Dalibor .

SCIENCE SIGNALING, 2017, 10 (493)

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