Exploring Potential of Aspergillus sclerotiorum: Secondary Metabolites and Biotechnological Relevance

被引：7

作者：

Ibrahim, Sabrin R. M. ^{[1
,2
]}

Abdallah, Hossam M. ^{[3
,4
]}

Mohamed, Gamal A. ^{[3
]}

Deshmukh, Sunil K. ^{[5
,6
]}

机构：

[1] Batterjee Med Coll, Dept Chem, Preparatory Year Program, Jeddah 21442, Saudi Arabia

[2] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut 71526, Egypt

[3] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod & Alternat Med, Jeddah 21589, Saudi Arabia

[4] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt

[5] Greenvent Biotech Pvt Ltd, Res & Dev Div, Uruli Kanch 412202, Maharashtra, India

[6] Agpharm Bioinnovat LLP, Thapar Inst Engn & Technol, Incubatee Sci & Technol Entrepreneurs Pk STEP, Patiala 147004, Punjab, India

来源：

MYCOLOGICAL PROGRESS | 2023年 / 22卷 / 01期

关键词：

Fungi; Aspergillus sclerotiorum; Enzymes; Diketopiperazines; Lovastatin analogs; Biotechnological applications; STEREOSELECTIVE BIOREDUCTION; OCHRATOXIN PRODUCTION; CHEMICAL DIVERSITY; PENICILLIC ACID; ALPHA-AMYLASE; ASPERIDINE B; WHOLE CELLS; FUNGUS; BIOSYNTHESIS; OPTIMIZATION;

D O I：

10.1007/s11557-022-01856-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fungi have been proven to be an inexhaustible treasure for structural-unique bioactive metabolites. Aspergillus sclerotiorum (Aspergillaceae) is a source of different enzymes that could have potential biotechnological and industrial applications. Also, this fungus has the capacity to biosynthesize different metabolites: pyrazines, cyclic peptides, indole derivatives, diketopiperazines, butenolides, and lovastatin analogs with diversified bioactivities. It is noteworthy that diketopiperazines and butenolides are the most bioactive metabolites that possessed marked antimicrobial and cytotoxic potentials. The current review aims to discuss the metabolites produced by A. sclerotiorum, including their structures, bioactivities, and proposed biosynthesis, as well as the biotechnological applications of this fungus in the period from 1958 to September 2022. A total of 104 metabolites and 91 references have been listed.

引用

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