Editorial: The Application of Proteogenomics to Urine Analysis for the Identification of Novel Biomarkers of Prostate Cancer: An Exploratory Study

被引：0
|
作者：
Gamallat, Yaser [1 ,2 ]
Bismar, Tarek A. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Calgary, Arnie Charbonneau Canc Inst, Cumming Sch Med, Dept Pathol & Lab Med, Calgary, AB T2N 4N1, Canada
[2] Univ Calgary, Arnie Charbonneau Canc Inst, Cumming Sch Med, Dept Oncol Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada
[3] Rockyview Gen Hosp, Dept Pathol, Alberta Precis Labs, Calgary, AB T2V 1P9, Canada
[4] Rockyview Gen Hosp, Dept Lab Med, Alberta Precis Labs, Calgary, AB T2V 1P9, Canada
[5] Rockyview Gen Hosp, Prostate Canc Ctr, Calgary, AB T2V 1P9, Canada
来源：
CANCERS | 2023年 / 15卷 / 16期
关键词：
proteogenomics; prostate cancer; biomarker detection;
D O I：
10.3390/cancers15164143
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this editorial context, we aim to leverage the potential of proteogenomics, which integrates genomic and proteomic data, to discover novel biomarkers that can aid in the diagnosis and management of prostate cancer. We highlight the importance of proteogenomics for understanding the functional consequences of somatic mutations in cancer and demonstrating how proteogenomic analysis can provide insights into the effects of genetic alterations on the proteomic landscape and identify potential therapeutic targets. This article also emphasizes the potential of urine analysis for the detection of prostate cancer. Overall, our editorial paper provides general insights on the application of proteogenomics to urine analysis for the identification of novel biomarkers of prostate cancer.
引用
收藏
页数：5
相关论文
共 50 条
  • [41] PSGR and PCA3 as Biomarkers for the Detection of Prostate Cancer in Urine
    Rigau, Marina
    Morote, Juan
    Carmen Mir, Maria
    Ballesteros, Carlos
    Ortega, Israel
    Sanchez, Alex
    Colas, Eva
    Garcia, Marta
    Ruiz, Anna
    Abal, Miguel
    Planas, Jacques
    Reventos, Jaume
    Doll, Andreas
    PROSTATE, 2010, 70 (16) : 1760 - 1767
  • [42] Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics
    Kwon, Oh Kwang
    Ha, Yun-Sok
    Lee, Jun Nyung
    Kim, Sunjoo
    Lee, Hyesuk
    Chun, So Young
    Kwon, Tae Gyun
    Lee, Sangkyu
    CANCER GENOMICS & PROTEOMICS, 2019, 16 (04) : 273 - 286
  • [43] Identification of MicroRNAs as Viable Aggressiveness Biomarkers for Prostate Cancer
    Martinez-Gonzalez, Luis Javier
    Sanchez-Conde, Victor
    Gonzalez-Cabezuelo, Jose Maria
    Antunez-Rodriguez, Alba
    Andres-Leon, Eduardo
    Robles-Fernandez, Inmaculada
    Lorente, Jose Antonio
    Vazquez-Alonso, Fernando
    Alvarez-Cubero, Maria Jesus
    BIOMEDICINES, 2021, 9 (06)
  • [44] Proteomics analysis of urine reveals acute phase response proteins as candidate diagnostic biomarkers for prostate cancer
    Davalieva, Katarina
    Kiprijanovska, Sanja
    Komina, Selim
    Petrusevska, Gordana
    Zografska, Natasha Chokrevska
    Polenakovic, Momir
    PROTEOME SCIENCE, 2015, 13
  • [45] Proteomics analysis of urine reveals acute phase response proteins as candidate diagnostic biomarkers for prostate cancer
    Katarina Davalieva
    Sanja Kiprijanovska
    Selim Komina
    Gordana Petrusevska
    Natasha Chokrevska Zografska
    Momir Polenakovic
    Proteome Science, 13
  • [46] Searching for the Novel Specific Predictors of Prostate Cancer in Urine: The Analysis of 84 miRNA Expression
    Lekchnov, Evgeniy A.
    Amelina, Evgeniya V.
    Bryzgunova, Olga E.
    Zaporozhchenko, Ivan A.
    Konoshenko, Mariya Yu.
    Yarmoschuk, Sergey V.
    Murashov, Ivan S.
    Pashkovskaya, Oxana A.
    Gorizkii, Anton M.
    Zheravin, Aleksandr A.
    Laktionov, Pavel P.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (12)
  • [47] Novel Histopathological Biomarkers in Prostate Cancer: Implications and Perspectives
    Kielb, Pawel
    Kowalczyk, Kamil
    Gurwin, Adam
    Nowak, Lukasz
    Krajewski, Wojciech
    Sosnowski, Roman
    Szydelko, Tomasz
    Malkiewicz, Bartosz
    BIOMEDICINES, 2023, 11 (06)
  • [48] Multi-Omics Analysis of Primary Prostate Cancer Datasets Reveals Novel Biomarkers
    Tuncer, Melis
    Karabekmez, Muhammed Erkan
    Collak, Filiz Kisaayak
    BIOCHEMICAL GENETICS, 2024,
  • [49] Diagnostic and Prognostic MicroRNA Biomarkers for Prostate Cancer in Cell-free Urine
    Fredsoe, Jacob
    Rasmussen, Anne K. I.
    Thomsen, Anni R.
    Mouritzen, Peter
    Hoyer, Soren
    Borre, Michael
    Orntoft, Torben F.
    Sorensen, Karina D.
    EUROPEAN UROLOGY FOCUS, 2018, 4 (06): : 825 - 833
  • [50] Novel Biomarkers for Risk of Prostate Cancer: Results From a Case-Control Study
    Yang, Li
    Gaikwad, Nilesh W.
    Meza, Jane
    Cavalieri, Ercole L.
    Muti, Paola
    Trock, Bruce
    Rogan, Eleanor G.
    PROSTATE, 2009, 69 (01) : 41 - 48
12345