Liquid Biopsy: An Emerging Diagnostic, Prognostic, and Predictive Tool in Gastric Cancer

被引：16
作者：
Han, Hye Sook [1 ]
Lee, Keun-Wook [2 ,3 ]
机构：
[1] Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Coll Med, Dept Internal Med, Cheongju, South Korea
[2] Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Coll Med, Dept Internal Med, Seongnam, South Korea
[3] Seoul Natl Univ Bundang Hosp, Seoul Natl Univ, Coll Med, Dept Internal Med, 82 Gumi Ro 173beon Gil, Seongnam 13620, Guam, South Korea
来源：
JOURNAL OF GASTRIC CANCER | 2024年 / 24卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Gastric cancer; Liquid biopsy; Biomarker; CIRCULATING TUMOR-CELLS; POTENTIAL BIOMARKER; PLASMA DNA; SERUM; MARKER; SURVIVAL; CHEMOTHERAPY; PROGRESSION; VALIDATION; EXPRESSION;
D O I：
10.5230/jgc.2024.24.e5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Liquid biopsy, a minimally invasive procedure that causes minimal pain and complication risks to patients, has been extensively studied for cancer diagnosis and treatment. Moreover, it facilitates comprehensive quantification and serial assessment of the whole-body tumor burden. Several biosources obtained through liquid biopsy have been studied as important biomarkers for establishing early diagnosis, monitoring minimal residual disease, and predicting the prognosis and response to treatment in patients with cancer. Although the clinical application of liquid biopsy in gastric cancer is not as robust as that in other cancers, biomarker studies using liquid biopsy are being actively conducted in patients with gastric cancer. Herein, we aimed to review the role of various biosources that can be obtained from patients with gastric cancer through liquid biopsies, such as blood, saliva, gastric juice, urine, stool, peritoneal lavage fluid, and ascites, by dividing them into cellular and acellular components. In addition, we reviewed previous studies on the diagnostic, prognostic, and predictive biomarkers for gastric cancer using liquid biopsy and discussed the limitations of liquid biopsy and the challenges to overcome these limitations in patients with gastric cancer.
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页码：4 / 28
页数：25
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