Classification of regulatory T cells and their role in myocardial ischemia-reperfusion injury

被引：1
|
作者：
Li, Junlin [1 ,2 ,3 ]
Gong, Yajun [1 ,2 ]
Wang, Yiren [1 ,2 ]
Huang, Huihui [1 ,2 ]
Du, Huan [1 ,2 ]
Cheng, Lianying [4 ]
Ma, Cui [5 ]
Cai, Yongxiang [1 ,2 ]
Han, Hukui [1 ,2 ]
Tao, Jianhong [1 ,2 ]
Li, Gang [1 ,2 ]
Cheng, Panke [1 ,2 ,6 ]
机构：
[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Inst Cardiovasc Dis, Sch Med, Chengdu 610072, Peoples R China
[2] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Cardiol, Chengdu 610072, Peoples R China
[3] Second Peoples Hosp Neijiang, Dept Cardiol, Neijiang 641100, Peoples R China
[4] Chongqing Med Univ, Affiliated Hosp 1, Dept Integrated Tradit Chinese & Western Med, Chongqing 400016, Peoples R China
[5] Army Med Univ, Dept Math, Chongqing 400038, Peoples R China
[6] Ultrasound Cardiac Electrophysiol & Biomech Key La, Chengdu 610072, Peoples R China
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2024年 / 186卷
基金：
中国国家自然科学基金;
关键词：
Myocardial ischemia-reperfusion injury; Regulatory T cells; Immune inflammatory response; Microenvironment; Myocardial infarction; IMMUNOLOGICAL SELF-TOLERANCE; TGF-BETA; DENDRITIC CELLS; B-CELLS; CUTTING EDGE; NKT CELLS; ISCHEMIA/REPERFUSION INJURY; AUTOIMMUNE-DISEASE; FOXP3; EXPRESSION; CORONARY-ARTERY;
D O I：
10.1016/j.yjmcc.2023.11.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myocardial ischemia-reperfusion injury (MIRI) is closely related to the final infarct size in acute myocardial infarction (AMI). Therefore, reducing MIRI can effectively improve the prognosis of AMI patients. At the same time, the healing process after AMI is closely related to the local inflammatory microenvironment. Regulatory T cells (Tregs) can regulate various physiological and pathological immune inflammatory responses and play an important role in regulating the immune inflammatory response after AMI. However, different subtypes of Tregs have different effects on MIRI, and the same subtype of Tregs may also have different effects at different stages of MIRI. This article systematically reviews the classification and function of Tregs, as well as the role of various subtypes of Tregs in MIRI. A comprehensive understanding of the role of each subtype of Tregs can help design effective methods to control immune reactions, reduce MIRI, and provide new potential therapeutic options for AMI.
引用
收藏
页码：94 / 106
页数：13
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