Role of epigenetic regulation in glaucoma

被引：9

作者：

Feng, Lemeng ^{[1
,2
,3
]}

Wang, Chao ^{[1
,2
,3
]}

Zhang, Cheng ^{[1
,2
,3
]}

Zhang, Wulong ^{[1
,2
,3
]}

Song, Weitao ^{[1
,2
,3
]}

机构：

[1] Cent South Univ, Natl Clin Res Ctr Geriatr Dis, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China

[2] Cent South Univ, Eye Ctr, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China

[3] Hunan Key Lab Ophthalmol, Changsha 410008, Hunan, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 168卷

关键词：

Glaucoma; Histone modifications; DNA methylation; Non -coding RNA; M6A methylation; RETINAL GANGLION-CELLS; ACID-MEDIATED NEUROPROTECTION; TRABECULAR MESHWORK CELLS; I COLLAGEN EXPRESSION; EXTRACELLULAR-MATRIX; DNA METHYLATION; MESENCHYMAL TRANSITION; CAPSULE FIBROBLAST; AQUEOUS-HUMOR; CIRCULAR RNAS;

D O I：

10.1016/j.biopha.2023.115633

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Glaucoma is the world's leading irreversible blinding eye disease. Lowering intraocular pressure is currently the only effective clinical treatment. However, there is a lack of long-acting IOP-lowering drugs, and some patients still experience retinal ganglion cell loss even with good intraocular pressure control. Currently, there is no effective method for neuroprotection and regeneration in clinical practice for glaucoma. In recent years, epigenetics has been widely researched and reported for its role in glaucoma's neuroprotection and regeneration. This article reviews the changes in histone modifications, DNA methylation, non-coding RNA, and m6A methylation in glaucoma, aiming to provide new perspectives for glaucoma management, protection of retinal ganglion cells, and axon regeneration by understanding epigenetic alterations.

引用

页数：14

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