Sex differences in cognitive function among people with HIV-1 clade C infection in Northern India

被引：0

作者：

Sharma, Anchal ^{[1
]}

Mohanty, Manju ^{[2
]}

Salan, Teddy ^{[3
]}

Aggarwal, Deepika ^{[1
]}

Mandell, Lissa ^{[4
]}

Jones, Deborah L. ^{[4
]}

Arheart, Kristopher ^{[5
]}

Sharma, Aman ^{[6
]}

Vyas, Sameer ^{[1
]}

Singh, Paramjeet ^{[1
]}

Govind, Varan ^{[3
]}

Kumar, Mahendra ^{[4
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Radiodiag & Imaging, Chandigarh, Punjab, India

[2] Postgrad Inst Med Educ & Res, Dept Neurosurg, Chandigarh, Punjab, India

[3] Univ Miami, Dept Radiol, Miller Sch Med, Miami, FL 33146 USA

[4] Univ Miami, Miller Sch Med, Dept Psychiat, Miami, FL USA

[5] Univ Miami, Dept Publ Hlth, Miller Sch Med, Miami, FL USA

[6] Postgrad Inst Med Educ & Res, Dept Internal Med, Clin Immunol & Rheumatol Serv, Chandigarh, Punjab, India

来源：

JOURNAL OF NEUROVIROLOGY | 2023年 / 29卷 / 05期

基金：

美国国家卫生研究院;

关键词：

HIV-1; Clade C; Antiretroviral therapy naive; Cognitive functioning; Sex differences; NEUROCOGNITIVE IMPAIRMENT; INDIVIDUALS; WOMEN; PERFORMANCE; DEMENTIA; SUBTYPE; KAMPALA; RISK; MEN;

D O I：

10.1007/s13365-023-01166-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Human immunodeficiency virus-1 (HIV-1) clade C is the most prevalent form of HIV-1 comprising nearly 46% of global infections and is the dominant subtype in India. Despite its predominance, the impact of HIV-1 clade C infection on cognitive function has been understudied in comparison with other subtypes, notably clade B, which is primarily found in Europe and North America. Few studies have assessed cognitive impairment in antiretroviral therapy (ART) naive men and women with HIV-1 clade C infection. In this study conducted in Northern India, differences in neuropsychological functioning were compared between 109 participants (70 men, 39 women) with untreated HIV-1 clade C infection and 110 demographically matched healthy controls (74 men, 36 women). A comprehensive neuropsychological battery was used to examine depression, self-assessment of functioning, and cognitive performance in six domains of functioning. Group differences were assessed by HIV-1 status and sex, controlling for age and education. Results indicated that cognitive deficits were substantially greater among male participants with HIV-1 clade C compared to male controls in all domains of cognitive functioning; in contrast, women with HIV-1 clade C had only minor deficits compared to healthy female participants. In addition, a larger proportion of men with HIV-1 clade C exhibited high levels of depression than women with HIV-1 clade C. These findings suggest that untreated HIV-1 clade C infection in men can have debilitating effects on neuropsychological function and depression, and stress the importance of facilitating rapid access to treatment to reduce the impact of HIV-1 infection.

引用

页码：614 / 625

页数：12