Immune cell infiltration in the pancreas of type 1, type 2 and type 3c diabetes

被引：4

作者：

Kattner, Nicole ^{[1
]}

机构：

[1] Newcastle Univ, Translat & Clin Res Inst, Med Sch, Framlington Pl, Newcastle Upon Tyne, England

来源：

THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM | 2023年 / 14卷

关键词：

diabetes; fibrosis; inflammation; pancreatitis; ISLET-ASSOCIATED MACROPHAGES; B-LYMPHOCYTE DEPLETION; BETA-CELL; STELLATE CELLS; CYSTIC-FIBROSIS; T-CELLS; INSULIN-SECRETION; RECENT-ONSET; DOUBLE-BLIND; INFLAMMATION;

D O I：

10.1177/20420188231185958

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The different types of diabetes differ in disease pathogenesis but share the impairment or loss of & beta;-cell function leading to chronic hyperglycaemia. While immune cells are present throughout the whole pancreas in normality, their number and activation is increased in diabetes. Different patterns and composition of inflammation could be observed in type 1, type 2 and type 3c diabetes. Immune cells, pancreatic stellate cells and fibrosis were present in the islet microenvironment and could add to & beta;-cell dysfunction and therefore development and progression of diabetes. First studies investigating the use of anti-inflammatory drugs demonstrate their ability to rescue remaining & beta;-cell function and their potential benefit in diabetes treatment. This article provides an overview of immune cell infiltrates in different types of diabetes, highlights the knowledge of their impact on & beta;-cell function and introduces the potential of immunomodulatory strategies.

引用

页数：11

共 86 条

[1] Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis [J].

Apte, MV ;

Haber, PS ;

Darby, SJ ;

Rodgers, SC ;

McCaughan, GW ;

Korsten, MA ;

Pirola, RC ;

Wilson, JS .

GUT, 1999, 44 (04) :534-541

[2]

Atkinson MA, 2014, LANCET, V383, P69, DOI [10.1016/S0140-6736(13)60591-7, 10.1016/S0140-6736(18)31320-5]

[3] Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes [J].

Babon, Jenny Aurielle B. ;

DeNicola, Megan E. ;

Blodgett, David M. ;

Crevecoeur, Inne ;

Buttrick, Thomas S. ;

Maehr, Rene ;

Bottino, Rita ;

Naji, Ali ;

Kaddis, John ;

Elyaman, Wassim ;

James, Eddie A. ;

Haliyur, Rachana ;

Brissova, Marcela ;

Overbergh, Lut ;

Mathieu, Chantal ;

Delong, Thomas ;

Haskins, Kathryn ;

Pugliese, Alberto ;

Campbell-Thompson, Martha ;

Mathews, Clayton ;

Atkinson, Mark A. ;

Powers, Alvin C. ;

Harlan, David M. ;

Kent, Sally C. .

NATURE MEDICINE, 2016, 22 (12) :1482-+

[4] Identification, culture, and characterization of pancreatic stellate cells in rats and humans [J].

Bachem, MG ;

Schneider, E ;

Gross, H ;

Weidenbach, H ;

Schmid, RM ;

Menke, A ;

Siech, M ;

Beger, H ;

Grünert, A ;

Adler, G .

GASTROENTEROLOGY, 1998, 115 (02) :421-432

[5] Insulitis in type 2 diabetes [J].

Boeni-Schnetzler, M. ;

Ehses, J. A. ;

Faulenbach, A. ;

Donath, M. Y. .

DIABETES OBESITY & METABOLISM, 2008, 10 :201-204

[6] Structural abnormalities in islets from very young children with cystic fibrosis may contribute to cystic fibrosis-related diabetes [J].

Bogdani, Marika ;

Blackman, Scott M. ;

Ridaura, Cecilia ;

Belloc, Jean-Pierre ;

Powers, Alvin C. ;

Aguilar-Bryan, Lydia .

SCIENTIFIC REPORTS, 2017, 7

[7] Hyaluronan and Hyaluronan-Binding Proteins Accumulate in Both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate With Inflammatory Cells in Insulitis [J].

Bogdani, Marika ;

Johnson, Pamela Y. ;

Potter-Perigo, Susan ;

Nagy, Nadine ;

Day, Anthony J. ;

Bollyky, Paul L. ;

Wight, Thomas N. .

DIABETES, 2014, 63 (08) :2727-2743

[8] Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms [J].

Brozzi, Flora ;

Nardelli, Tarlliza R. ;

Lopes, Miguel ;

Millard, Isabelle ;

Barthson, Jenny ;

Igoillo-Esteve, Mariana ;

Grieco, Fabio A. ;

Villate, Olatz ;

Oliveira, Joana M. ;

Casimir, Marina ;

Bugliani, Marco ;

Engin, Feyza ;

Hotamisligil, Gokhan S. ;

Marchetti, Piero ;

Eizirik, Decio L. .

DIABETOLOGIA, 2015, 58 (10) :2307-2316

[9] Pancreatic β-Cell production of CXCR3 ligands precedes diabetes onset [J].

Burke, Susan J. ;

Karlstad, Michael D. ;

Eder, Adrianna E. ;

Regal, Kellie M. ;

Lu, Danhong ;

Burk, David H. ;

Collier, J. Jason .

BIOFACTORS, 2016, 42 (06) :703-715

[10] The diagnosis of insulitis in human type 1 diabetes [J].

Campbell-Thompson, M. L. ;

Atkinson, M. A. ;

Butler, A. E. ;

Chapman, N. M. ;

Frisk, G. ;

Gianani, R. ;

Giepmans, B. N. ;

von Herrath, M. G. ;

Hyoty, H. ;

Kay, T. W. ;

Korsgren, O. ;

Morgan, N. G. ;

Powers, A. C. ;

Pugliese, A. ;

Richardson, S. J. ;

Rowe, P. A. ;

Tracy, S. ;

Veld, P. A. In't .

DIABETOLOGIA, 2013, 56 (11) :2541-2543

← 1 2 3 4 5 6 7 8 9 →