Application of Nanotechnology-Based Products in Stroke

Strokeis a disease with high disability and high mortality inthe world. Due to the existence of the blood-brain barrier (BBB),complex brain structure, and numerous neural signal pathways, thetreatment methods are limited, so new drugs and new treatments needto be developed urgently. Thankfully, the advent of nanotechnologyoffered a new opportunity for biomedical development because of theunique properties of nanoparticles that give them the ability to traversethe BBB and accumulate in relevant regions of the brain. More importantly,nanoparticles could be modified on the surface to meet a variety ofspecific properties that people need. Some could be used for effectivedrug delivery, including tissue plasminogen activator (tPA), neuroprotectiveagents, genes, and cytokines; some nanoparticles were used as contrastagents and biosensors in medical imaging for further diagnosis ofstroke; some were used to track target cells for prognosis of stroke;and some were used to detect pathological markers of stroke that appearat different stages. This Review looks at the application and researchprogress of nanoparticles in the diagnosis and treatment of stroke,hoping to bring some help to researchers.