A single magnetic nanoplatform-mediated combination therapy of immune checkpoint silencing and magnetic hyperthermia for enhanced anti-cancer immunity

被引：7

作者：

Yang, Zhiyu ^{[1
,2
,4
]}

Guo, Xiaoya ^{[1
,2
,4
]}

Meng, Meng ^{[1
,2
,4
]}

Li, Tong ^{[1
,2
,4
]}

Fang, Huapan ^{[3
,5
]}

Tang, Zhaohui ^{[1
,2
,4
]}

Tian, Huayu ^{[1
,2
,3
,4
,5
]}

Chen, Xuesi ^{[1
,2
,4
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

[2] Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Peoples R China

[3] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[4] Jilin Biomed Polymers Engn Lab, Changchun 130022, Peoples R China

[5] Innovat Lab Sci & Technol Energy Mat Fujian Prov I, Xiamen 361005, Peoples R China

来源：

NANO RESEARCH | 2023年 / 16卷 / 08期

基金：

中国国家自然科学基金;

关键词：

magnetic nanoclusters; gene therapy; immune checkpoint silencing; magnetic hyperthermia therapy; cancer immunotherapy; TUMOR; IMMUNOTHERAPY; CANCER;

D O I：

10.1007/s12274-023-5839-z

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

As a revolutionary cancer treatment strategy, immunotherapy has attracted great attention. However, the effect of immunotherapy such as immune checkpoint blockade (ICB) is usually limited by insufficient immune response in the body. Herein, a polycation-based magnetic nanocluster platform was developed to load therapeutic nucleic acids, which could achieve gene therapy-mediated ICB and efficient magnetic hyperthermia therapy (MHT). The silencing of immune checkpoints together with MHT-induced immunogenic cell death (ICD) effectively alleviated the immune escape of cancer cells and significantly enhanced the visibility of cancer cells to the immune system. This combined treatment strategy activated a strong adaptive anticancer immune response in vivo, greatly inhibiting tumor growth, metastasis and recurrence.

引用

页码：11206 / 11215

页数：10

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