Photoredox Microfluidic Synthesis of Trifluoromethylated Amino Acids

被引：5

作者：

Liu, Jiyang ^{[1
]}

Zhang, Weigang ^{[1
]}

Tao, Xiangzhang ^{[1
]}

Wang, Qing ^{[1
]}

Wang, Xiaochen ^{[1
]}

Pan, Yi ^{[1
]}

Ma, Jinzhu ^{[2
]}

Yan, Liang ^{[1
,2
]}

Wang, Yi ^{[1
]}

机构：

[1] Nanjing Univ, Collaborat Innovat Ctr Adv Microstruct, Sch Chem & Chem Engn, State Key Lab Coordinat Chem,Jiangsu Key Lab Adv O, Nanjing 210023, Peoples R China

[2] Wannan Med Coll, Sch Basic Med, Wuhu 241000, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 17期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

MEDICINAL CHEMISTRY; FLUORINE; 4-ALKYL-1,4-DIHYDROPYRIDINES; DERIVATIVES; ALKYLATION; DESIGN; IMINES; ESTERS;

D O I：

10.1021/acs.orglett.3c00915

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluorinated amino acids are a class of highly valuable building blocks that are widely employed in biological science and pharmaceutical industry for improved stability, activity, and folding property of proteins. However, the synthetic approach has conventionally been constrained by harsh conditions and limited substrate range. We demonstrate a general synthetic protocol for photoinduced alpha-CF3 amino acids using continuous flow technology that benefits from enhanced fusion and precise control of reaction time, making it potentially useful in large-scale peptide synthesis.

引用

页码：3083 / 3088

页数：6

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