The interplay between neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, erectile dysfunction, and Peyronie?s disease: A meta-analysis of observational studies

被引:1
作者
Pakpahan, Cennikon [1 ,2 ,3 ]
Ilhamsyah, Ilhamsyah [1 ,2 ,3 ]
Supardi, Supardi [1 ,2 ,3 ]
Narulita, Pety [1 ,2 ,3 ]
Agustinus, Agustinus [1 ,2 ,3 ]
Darmadi, Darmadi [1 ,2 ,3 ,4 ]
机构
[1] Univ Airlangga, Fac Med, Androl Study Program, Surabaya, Indonesia
[2] Univ Airlangga, Fac Med, Dept Biomed Sci, Surabaya, Indonesia
[3] Gen Acad Dr Soetomo Hosp, Androl Outpatient Clin, Surabaya, Indonesia
[4] Univ Sumatera Utara, Fac Med, Dept Internal Med, Medan, Indonesia
关键词
Peyronie?s disease; Sexual health care; NLR; PLR; Inflammatory; Erectile dysfunction;
D O I
10.4081/aiua.2023.11162
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Introduction: This study aims to investigate the relationship between NeutrophilMethods: We conducted a meta-analysis of the observational study by searching for the appropriate keywords in eight databases. The risk of publication bias of the included studies was assessed by Egger's test and Kendall's t. The data extraction was carried out for each study and analysed using Revman 5.0. Results: There were eleven eligible studies out of the 411 studies retrieved. Eight studies were conducted on cases of erectile dysfunction, and three studies on Peyronie's disease. There was a significant relationship between NLR, PLR and ED (SMD: 0.59, 95% CI: 0.33-0.85 and SMD: 0.64, 95% CI: 0.13-1.16, respectively). The same was also found for PD. The active phase of PD tended to have higher NLR (SMD: 0.68, 95% CI: 0.43-0.92) and PLR (SMD: 0.27, 95% CI: 0.06-0.49) compared to the chronic phase. No publication bias was found in both ED and PD studies. Conclusions: NLR and PLR indicate an ongoing inflammatory process in both ED and PD. These findings can be used as markers of treatment and prognosis of both diseases in sexual health care.
引用
收藏
页数:6
相关论文
共 21 条
  • [1] The relationship between platelet-lymphocyte ratio and severity of erectile dysfunction
    Akbas, Alpaslan
    Gulpinar, Murat Tolga
    Sancak, Eyup Burak
    Gunes, Mustafa
    Ucar, Murat
    Altok, Muammer
    Umul, Mehmet
    [J]. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2016, 32 (02) : 91 - 95
  • [2] Aslan A, 2019, UROL J, V16, P216, DOI 10.22037/uj.v16i2.5011
  • [3] Supporting the role of penile trauma and micro-trauma in the etiology of Peyronie's disease. Prospective observational study using the electronic microscope to examine two types of plaques
    De Rose, Aldo Franco
    Mantica, Guglielmo
    Bocca, Bruna
    Szpytko, Alexander
    Van der Merwe, Andre
    Terrone, Carlo
    [J]. AGING MALE, 2020, 23 (05) : 740 - 745
  • [4] Comparison of hormone profile and systemic inflammation in patients presenting with sexual dysfunction: Which is important?
    Demirci, Aykut
    Ozgur, Berat Cem
    Tuncer, Sibel Cigdem
    [J]. REVISTA INTERNACIONAL DE ANDROLOGIA, 2021, 19 (04): : 242 - 248
  • [5] The effect of using tadalafil 5 mg/day on neutrophil-lymphocyte and platelet-lymphocyte ratios in mild-medium and severe erectile dysfunction patients; and comparison of clinical response
    Demirci, Aykut
    Ozgur, Berat Cem
    [J]. ANDROLOGIA, 2019, 51 (09)
  • [6] Proposal: Trauma as the cause of the Peyronie's lesion
    Devine, CJ
    Somers, KD
    Jordan, GH
    Schlossberg, SM
    [J]. JOURNAL OF UROLOGY, 1997, 157 (01) : 285 - 290
  • [7] The pathophysiology of Peyronie's disease
    El-Sakka, Ahmed I.
    Salabas, Emre
    Dincer, Murat
    Kadioglu, Ates
    [J]. ARAB JOURNAL OF UROLOGY, 2013, 11 (03) : 272 - 277
  • [8] Red blood cell distribution width values in erectile dysfunction
    Erdogan, Abdullah
    Keskin, Ercument
    Sambel, Murat
    [J]. REVISTA INTERNACIONAL DE ANDROLOGIA, 2022, 20 (01): : 24 - 30
  • [9] Role of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Peyronie's disease: a new diagnostic approach to predict the stage of the disease?
    Garcia Rojo, Esther
    Garcia Gomez, Borja
    Santos-Perez de la Blanca, Rocio
    Manfredi, Celeste
    Alonso Isa, Manuel
    Medina Polo, Jose
    Rodriguez Antolin, Alfredo
    Romero Otero, Javier
    [J]. ASIAN JOURNAL OF ANDROLOGY, 2021, 23 (03) : 325 - 329
  • [10] Are neutrophil-lymphocyte and platelet-lymphocyte ratios useful for determining active phase of Peyronie's disease?
    Greenberg, Jacob W.
    Kim, Joseph
    Pincus, Joshua
    Sandberg, Maxwell L.
    Dick, Brian
    Greenberg, Rachel M.
    Raheem, Omer
    Hellstrom, Wayne J. G.
    [J]. JOURNAL OF CLINICAL UROLOGY, 2024, 17 (05) : 525 - 532