Zebrafish as a Model Organism for Studying Pathologic Mechanisms of Neurodegenerative Diseases and other Neural Disorders

被引：15

作者：

Liu, Yanying ^{[1
]}

机构：

[1] Qingdao Huanghai Univ, Sch Nursing & Hlth, Dept Basic Med, Qingdao 266427, Peoples R China

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2023年 / 43卷 / 06期

关键词：

Neurodegenerative diseases; Zebrafish; Alzheimer's disease; Parkinson's disease; Amyotrophic lateral sclerosis; Huntington's disease; PARKINSONS-DISEASE; BRAIN; AUTOPHAGY; MOTOR; DEFICIENCY; HUNTINGTIN; KNOCKDOWN; SYNUCLEIN; NEURONS; PROTEIN;

D O I：

10.1007/s10571-023-01340-w

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Zebrafish are widely considered an excellent vertebrate model for studying the pathogenesis of human diseases because of their transparency of embryonic development, easy breeding, high similarity with human genes, and easy gene manipulation. Previous studies have shown that zebrafish as a model organism provides an ideal operating platform for clarifying the pathological and molecular mechanisms of neurodegenerative diseases and related human diseases. This review mainly summarizes the achievements and prospects of zebrafish used as model organisms in the research of neurodegenerative diseases and other human diseases related to the nervous system in recent years. In the future study of human disease mechanisms, the application of the zebrafish model will continue to provide a valuable operating platform and technical support for investigating and finding better prevention and treatment of these diseases, which has broad application prospects and practical significance.

引用

页码：2603 / 2620

页数：18

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