Functional Assessment of Coronary Artery Stenosis from Coronary Angiography and Computed Tomography: Angio-FFR vs. CT-FFR

被引：5

作者：

Guan, Xueqiang ^{[1
,2
]}

Song, Dan ^{[3
]}

Li, Changling ^{[4
]}

Hu, Yumeng ^{[5
]}

Leng, Xiaochang ^{[5
]}

Sheng, Xiaosheng ^{[6
]}

Bao, Lifang ^{[7
]}

Pan, Yibin ^{[8
]}

Dong, Liang ^{[4
]}

Jiang, Jun ^{[4
]}

Xiang, Jianping ^{[5
]}

Jiang, Wenbing ^{[9
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Cardiol, Wenzhou, Peoples R China

[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China

[3] Wuhan Asia Heart Hosp, Dept Cardiol, Wuhan, Peoples R China

[4] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Cardiol, Hangzhou, Peoples R China

[5] ArteryFlow Technol Co Ltd, Hangzhou, Peoples R China

[6] Jinhua Peoples Hosp, Dept Cardiol, Jinhua, Peoples R China

[7] Jinhua Municipal Cent Hosp, Dept Electrophysiol, Jinhua, Peoples R China

[8] Jinhua Municipal Cent Hosp, Dept Cardiol, Jinhua, Peoples R China

[9] Wenzhou Med Univ, Clin Inst 3, Dept Cardiol, Wenzhou, Peoples R China

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2023年 / 16卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Fractional flow reserve; CT-FFR; Angio-FFR; Coronary artery disease; FRACTIONAL FLOW RESERVE; DIAGNOSTIC PERFORMANCE; ACCURACY; LESIONS; QFR;

D O I：

10.1007/s12265-023-10361-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study was designed to compare the diagnostic performance of angio-FFR and CT-FFR for detecting hemodynamically significant coronary stenosis. Angio-FFR and CT-FFR were measured in 110 patients (139 vessels) with stable coronary disease using invasive FFR as the reference standard. On per-patient basis, angio-FFR was highly correlated with FFR (r =0.78, p < 0.001), while the correlation was moderate between CT-FFR and FFR (r =0.68, p < 0.001). Diagnostic accuracy, sensitivity, and specificity for angio-FFR were 94.6%, 91.4%, and 96.0%, respectively; and those of CT-FFR were 91.8%, 91.4%, and 92%, respectively. Bland-Altman analysis showed that angio-FFR had a larger average difference and a smaller root mean squared deviation than CT-FFR compared with FFR (-0.014 +/-.056 vs. 0.0003 +/- 0.072). Angio-FFR had a slightly higher AUC than that of CT-FFR (0.946 vs. 0.935, p =0.750). Angio-FFR and CT-FFR computed from coronary images could be accurate and efficient computational tools for detecting lesion-specific ischemia of coronary artery stenosis.

引用

页码：905 / 915

页数：11

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