Characteristics and risk factors for post-COVID-19 breathlessness after hospitalisation for COVID-19

被引：14

作者：

Daines, Luke ^{[1
]}

Zheng, Bang ^{[1
]}

Elneima, Omer ^{[2
]}

Harrison, Ewen ^{[1
]}

Lone, Nazir I. ^{[1
]}

Hurst, John R. ^{[3
]}

Brown, Jeremy S. ^{[3
]}

Sapey, Elizabeth ^{[4
]}

Chalmers, James D. ^{[5
]}

Quint, Jennifer K. ^{[6
]}

Pfeffer, Paul ^{[7
]}

Siddiqui, Salman ^{[2
]}

Walker, Samantha ^{[8
]}

Poinasamy, Krisnah ^{[8
]}

McAuley, Hamish ^{[2
]}

Sereno, Marco ^{[2
]}

Shikotra, Aarti ^{[2
]}

Singapuri, Amisha ^{[2
]}

Docherty, Annemarie B. ^{[1
]}

Marks, Michael ^{[9
]}

Toshner, Mark ^{[10
]}

Howard, Luke S. ^{[11
]}

Horsley, Alex ^{[12
]}

Jenkins, Gisli

Porter, Joanna C. ^{[3
]}

Ho, Ling-Pei ^{[13
]}

Raman, Betty ^{[14
]}

Wain, Louise V. ^{[15
]}

Brightling, Christopher E. ^{[2
]}

Evans, Rachael A. ^{[2
]}

Heaney, Liam G. ^{[16
]}

De Soyza, Anthony ^{[17
]}

Sheikh, Aziz ^{[1
]}

机构：

[1] Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland

[2] Univ Leicester, Inst Lung Hlth, Leicester NIHR Biomed Res Ctr, Leicester, Leics, England

[3] UCL, UCL Resp, London, England

[4] Univ Birmingham, Ctr Translat Inflammat Res, Birmingham, W Midlands, England

[5] Univ Dundee, Sch Med, Dundee, Scotland

[6] Imperial Coll London, Natl Heart & Lung Inst, London, England

[7] Barts Hlth NHS Trust & Queen Mary Univ London, London, England

[8] Asthma Lung UK, London, England

[9] London Sch Hyg & Trop Med, Clin Res Dept, London, England

[10] Univ Cambridge, Heart Lung Res Inst, Dept Med, Cambridge, England

[11] Hammersmith Hosp, Imperial Coll Healthcare NHS Trust, London, England

[12] Univ Manchester, Div Infect Immun & Resp Med, Manchester, Lancs, England

[13] Univ Oxford, MRC Weatherall Inst Mol Med, Oxford, England

[14] Univ Oxford, Radcliffe Dept Med, Oxford, England

[15] Univ Leicester, Dept Hlth Sci & NIHR Leicester Biomed Res Ctr, Leicester, Leics, England

[16] Queens Univ Belfast, Ctr Expt Med, Belfast, Antrim, North Ireland

[17] Newcastle Univ, Populat Hlth Sci Inst, Newcastle, NSW, Australia

来源：

ERJ OPEN RESEARCH | 2023年 / 9卷 / 01期

基金：

英国科研创新办公室;

关键词：

SPIROMETRY;

D O I：

10.1183/23120541.00274-2022

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background Persistence of respiratory symptoms, particularly breathlessness, after acute coronavirus disease 2019 (COVID-19) infection has emerged as a significant clinical problem. We aimed to characterise and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalisation. Methods PHOSP-COVID is a multicentre prospective cohort study of UK adults hospitalised for COVID-19. Clinical data were collected during hospitalisation and at a follow-up visit. Breathlessness was measured by a numeric rating scale of 0-10. We defined post-COVID-19 breathlessness as an increase in score of.1 compared to the pre-COVID-19 level. Multivariable logistic regression was used to identify risk factors and to develop a prediction model for post-COVID-19 breathlessness. Results We included 1226 participants (37% female, median age 59 years, 22% mechanically ventilated). At a median 5 months after discharge, 50% reported post-COVID-19 breathlessness. Risk factors for postCOVID-19 breathlessness were socioeconomic deprivation (adjusted OR 1.67, 95% CI 1.14-2.44), preexisting depression/anxiety (adjusted OR 1.58, 95% CI 1.06-2.35), female sex (adjusted OR 1.56, 95% CI 1.21-2.00) and admission duration (adjusted OR 1.01, 95% CI 1.00-1.02). Black ethnicity (adjusted OR 0.56, 95% CI 0.35-0.89) and older age groups (adjusted OR 0.31, 95% CI 0.14-0.66) were less likely to report post-COVID-19 breathlessness. Post-COVID-19 breathlessness was associated with worse performance on the shuttle walk test and forced vital capacity, but not with obstructive airflow limitation. The prediction model had fair discrimination (concordance statistic 0.66, 95% CI 0.63-0.69) and good calibration (calibration slope 1.00, 95% CI 0.80-1.21). Conclusions Post-COVID-19 breathlessness was commonly reported in this national cohort of patients hospitalised for COVID-19 and is likely to be a multifactorial problem with physical and emotional components.

引用

页数：15

共 43 条

[1] The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease [J].

Adeloye, Davies ;

Elneima, Omer ;

Daines, Luke ;

Poinasamy, Krisnah ;

Quint, Jennifer K. ;

Walker, Samantha ;

Brightling, Chris E. ;

Siddiqui, Salman ;

Hurst, John R. ;

Chalmers, James D. ;

Pfeffer, Paul E. ;

Novotny, Petr ;

Drake, Thomas M. ;

Heaney, Liam G. ;

Rudan, Igor ;

Sheikh, Aziz ;

De Soyza, Anthony .

LANCET RESPIRATORY MEDICINE, 2021, 9 (12) :1467-1478

[2]

[Anonymous], 2019, Health Survey for England - Health, social care and lifestyles

[3]

[Anonymous], 2019, STAT OBESITY PHYS AC

[4]

Ayoubkhani D., 2022, PREVALENCE ONGOING S

[5] The Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5): Development and Initial Psychometric Evaluation [J].

Blevins, Christy A. ;

Weathers, Frank W. ;

Davis, Margaret T. ;

Witte, Tracy K. ;

Domino, Jessica L. .

JOURNAL OF TRAUMATIC STRESS, 2015, 28 (06) :489-498

[6] Respiratory rehabilitation for Covid-19 related persistent dyspnoea: A one-year experience [J].

Bouteleux, Benoit ;

Henrot, Pauline ;

Ernst, Rachel ;

Grassion, Leo ;

Raherison-Semjen, Chantal ;

Beaufils, Fabien ;

Zysman, Maeva ;

Delorme, Mathieu .

RESPIRATORY MEDICINE, 2021, 189

[7] Predictors of chronic breathlessness: a large population study [J].

Bowden, Jacqueline A. ;

To, Timothy H. M. ;

Abernethy, Amy P. ;

Currow, David C. .

BMC PUBLIC HEALTH, 2011, 11

[8] Prevalence of potential respiratory symptoms in survivors of hospital admission after coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis [J].

Cares-Marambio, Kevin ;

Montenegro-Jimenez, Yessenia ;

Torres-Castro, Rodrigo ;

Vera-Uribe, Roberto ;

Torralba, Yolanda ;

Alsina-Restoy, Xavier ;

Vasconcello-Castillo, Luis ;

Vilaro, Jordi .

CHRONIC RESPIRATORY DISEASE, 2021, 18

[9] Functional outcome after inpatient rehabilitation in postintensive care unit COVID-19 patients: findings and clinical implications from a real-practice retrospective study [J].

Curci, Claudio ;

Negrini, Francesco ;

Ferrillo, Martina ;

Bergonzi, Roberto ;

Bonacci, Eleonora ;

Camozzi, Danila M. ;

Ceravolo, Claudia ;

De Franceschi, Silvia ;

Guarnieri, Rodolfo ;

Moro, Paolo ;

Pisano, Fabrizio ;

De Sire, Alessandro .

EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE, 2021, 57 (03) :443-450

[10] Chest radiography is a poor predictor of respiratory symptoms and functional impairment in survivors of severe COVID-19 pneumonia [J].

D'Cruz, Rebecca F. ;

Waller, Michael D. ;

Perrin, Felicity ;

Periselneris, Jimstan ;

Norton, Sam ;

Smith, Laura-Jane ;

Patrick, Tanya ;

Walder, David ;

Heitmann, Amadea ;

Lee, Kai ;

Madula, Rajiv ;

McNulty, William ;

Macedo, Patricia ;

Lyall, Rebecca ;

Warwick, Geoffrey ;

Galloway, James B. ;

Birring, Surinder S. ;

Patel, Amit ;

Patel, Irem ;

Jolley, Caroline J. .

ERJ OPEN RESEARCH, 2021, 7 (01) :1-13

← 1 2 3 4 5 →