Reliability and feasibility of home-based dried blood spot in therapeutic drug monitoring: a systematic review and meta-analysis

被引：4
作者：
Xiaoyong, Xu [1 ]
Xilin, Ge [1 ]
Guangfei, Wang [1 ]
Wei, Wu [1 ]
Xiaowen, Zhai [2 ]
Hong, Xu [3 ]
Huimin, Zhang [4 ]
Zhiping, Li [1 ]
机构：
[1] Fudan Univ, Childrens Hosp, Natl Childrens Med Ctr, Dept Clin Pharm, 399 Wanyuan Rd, Shanghai 201102, Peoples R China
[2] Fudan Univ, Childrens Hosp, Natl Childrens Med Ctr, Dept Hematol & Oncol, Shanghai 201102, Peoples R China
[3] Fudan Univ, Childrens Hosp, Natl Childrens Med Ctr, Dept Nephrol, Shanghai 201102, Peoples R China
[4] China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Peoples R China
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 2023年 / 79卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Self-sampled DBS; Therapeutic drug monitoring; Agreement; Adherence; Yield; Preference; TANDEM MASS-SPECTROMETRY; CYCLOSPORINE-A; LC-MS/MS; CLINICAL VALIDATION; TACROLIMUS; HEMATOCRIT; EVEROLIMUS; SIROLIMUS; TAMOXIFEN; ADHERENCE;
D O I：
10.1007/s00228-022-03417-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Purpose Dried blood spot (DBS) is one of promising home sampling methods for therapeutic drug monitoring (TDM). However, the associated reliability and feasibility (including yield, adherence, and preference), which are criteria for the promotion of home-based DBS, remain unknown. This systematic review and meta-analysis aimed to evaluate the reliability and feasibility of TDM using DBS sampling. Methods In this study, a combination of MeSH and free terms for (dried blood spot*[title/abstract])AND ( "Drug Monitoring "[Mesh])AND(home OR venous)was surveyed using EMBASE, PubMed, Cochrane Library, and Web of Science upon gathering published. we registered this study protocol with the International Prospective Registry of Systematic Reviews (CRD42021247559). Results Approximately half (35/75) of the evaluations reported good agreement between DBS and plasma, and the results for drugs with poor agreement may be improved using a haematocrit-based physiological equation. The yield and adherence to home-based DBS exceeded 87%, and questionnaire-based preference for DBS was 77%. Conclusions DBS may be a reliable and feasible home sampling method; however, it requires intricate design and evaluation before implementation.
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页码：183 / 193
页数：11
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