Systemic Immune-inflammation Index in Patients with Migraine: Clinical, Scale and Radiological Characteristics

Aim: Migraine is a common neurological disorder in which inflammation plays a role in its pathophysiology. Systemic immune inflammation index (SII) (platelet x neutrophil/lymphocyte) is a vital parameter that indicates inflammatory response and is used in follow-up and evaluation of prognosis for various diseases. The aim of this study is to compare the hematological parameters of patients with migraine and healthy controls and to determine the correlation between SII with the clinical features of migraine and migraine-related hyperintense lesions on brain magnetic Materials and Methods: Migraine patients over 18 years old, who were admitted to the neurology outpatient clinic in a 48-month period, were included in the study. Healthy individuals were included in the study as the control group. Age, gender, duration of migraine diagnosis, migraine attack frequency, presence of aura, smoking, family history, presence of systemic disease, visual analog scale and migraine disability scale scores, presence of migraine-related hyperintense lesions on brain MRI were recorded for all patients in the study. Hemoglobin (Hb), red cell distribution width (RDW), neutrophil, lymphocyte, thrombocyte counts and SII values of the control group and migraine patients were compared. Results: Hb, lymphocyte, thrombocyte, and RDW levels were significantly higher in migraine patients (n=150) than in the control group (n=178) (p=0.03, p=0.05, p=0.002, p=0.000, respectively). SII was found to be significantly higher in female patients with a diagnosis of migraine compared to males (p=0.01). RDW value was significantly higher in patients with hyperintense lesions on MRI than in those without lesions (p=0.001). Conclusion: In our study, it is thought that RDW in patients with migraine may be a marker for the presence of migraine-related hyperintense lesions on MRI. However, although SII had a difference between genders in migraine, it has been observed that it is not a parameter that will contribute to the prediction for the disease for now.