A copper(<sc>ii</sc>) bromide/NMO system for α-amination of esters under continuous-flow conditions with reduced catalyst loading

被引：2
作者：
Chauhan, Yaman [1 ]
Kumar, Kankanala Naveen [1 ]
Ravichandiran, V. [1 ]
Jethy, Sonali Bindita [1 ]
Mohanta, Nirmala [1 ]
Swain, Sharada Prasanna [1 ]
机构：
[1] Natl Inst Pharmaceut Educ & Res Kolkata, Dept Med Chem, 168 Maniktala Main Rd, Kolkata 700054, India
来源：
NEW JOURNAL OF CHEMISTRY | 2024年 / 48卷 / 14期
关键词：
EFFICIENT; GREEN;
D O I：
10.1039/d3nj05456j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new copper(ii) bromide/N-methylmorpholine N-oxide (NMO)-promoted method for alpha-amination of esters under continuous-flow conditions, with reduced catalyst loading is reported. The alpha-amino esters are precursors for the synthesis of alpha-amino acids. This method provides alpha-amino esters in 58-83% yields. The desired Cu(ii)Br catalyst is regenerated by in situ oxidation of Cu(i)Br in the presence of NMO.
引用
收藏
页码：6095 / 6102
页数：8
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