Exosomal microRNAs: implications in the pathogenesis and clinical applications of subarachnoid hemorrhage

被引:3
作者
Liao, Lishang [1 ]
Wang, Haoran [1 ]
Wei, Deli [2 ]
Yi, Mingliang [2 ]
Gu, Yingjiang [1 ,2 ]
Zhang, Mingwei [1 ]
Wang, Li [3 ]
机构
[1] Southwest Med Univ, Dept Neurosurg, Affiliated Tradit Chinese Med Hosp, Luzhou, Peoples R China
[2] Peoples Hosp Fushun Cty, Dept Neurosurg, Zigong, Peoples R China
[3] Southwest Med Univ, Dept Res Ctr Integrated Tradit Chinese & Western M, Affiliated Tradit Chinese Med Hosp, Luzhou, Peoples R China
来源
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2023年 / 16卷
关键词
subarachnoid hemorrhage; early brain injury; exosomal micro-RNAs; apoptosis; inflammatory response; immune activation; EXTRACELLULAR VESICLES; BRAIN-INJURY; OXIDATIVE STRESS; BIOGENESIS; EXPRESSION; CANCER; CELLS; IDENTIFICATION; MECHANISM; RNAS;
D O I
10.3389/fnmol.2023.1300864
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Subarachnoid hemorrhage (SAH) is a severe acute neurological disorder with a high fatality rate. Early brain injury (EBI) and cerebral vasospasm are two critical complications of SAH that significantly contribute to poor prognosis. Currently, surgical intervention and interventional therapy are the main treatment options for SAH, but their effectiveness is limited. Exosomes, which are a type of extracellular vesicles, play a crucial role in intercellular communication and have been extensively studied in the past decade due to their potential influence on disease progression, diagnosis, and treatment. As one of the most important components of exosomes, miRNA plays both direct and indirect roles in affecting disease progression. Previous research has found that exosomal miRNA is involved in the development of various diseases, such as tumors, chronic hepatitis, atherosclerosis, diabetes, and SAH. This review focuses on exploring the impact of exosomal miRNA on SAH, including its influence on neuronal apoptosis, inflammatory response, and immune activation following SAH. Furthermore, this review highlights the potential clinical applications of exosomal miRNA in the treatment of SAH. Although current research on this topic is limited and the clinical application of exosomal miRNA has inherent limitations, we aim to provide a concise summary of existing research progress and offer new insights for future research directions and trends in this field.
引用
收藏
页数:13
相关论文
共 141 条
  • [1] Regulation of adipogenesis by exosomal milk miRNA
    Abbas, Manal A.
    Al-Saigh, Noor Nadhim
    Saqallah, Fadi G.
    [J]. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2023, 24 (02) : 297 - 316
  • [2] Circulating exosomal miRNAs in cardiovascular disease pathogenesis: New emerging hopes
    Aghabozorgi, Amirsaeed S.
    Ahangari, Najmeh
    Eftekhaari, Tasnim E.
    Torbati, Paria N.
    Bahiraee, Alireza
    Ebrahimi, Reyhane
    Pasdar, Alireza
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (12) : 21796 - 21809
  • [3] miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development
    Akers, Johnny C.
    Ramakrishnan, Valya
    Kim, Ryan
    Skog, Johan
    Nakano, Ichiro
    Pingle, Sandeep
    Kalinina, Juliya
    Hua, Wei
    Kesari, Santosh
    Mao, Ying
    Breakefield, Xandra O.
    Hochberg, Fred H.
    Van Meir, Erwin G.
    Carter, Bob S.
    Chen, Clark C.
    [J]. PLOS ONE, 2013, 8 (10):
  • [4] Clinical Outcome and Prognostic Factors of Patients with Perimesencephalic and Nonperimesencephalic Subarachnoid Hemorrhage
    Angermann, Manuel
    Jablawi, Fidaa
    Angermann, Maike
    Conzen-Dilger, Catharina
    Schubert, Gerrit A.
    Hollig, Anke
    Veldeman, Michael
    Reich, Arno
    Hasan, Dimah
    Ridwan, Hani
    Clusmann, Hans
    Wiesmann, Martin
    Nikoubashman, Omid
    [J]. WORLD NEUROSURGERY, 2022, 165 : E512 - E519
  • [5] Exosomes provide unappreciated carrier effects that assist transfers of their miRNAs to targeted cells; I. They are 'The Elephant in the Room'
    Askenase, Philip W.
    [J]. RNA BIOLOGY, 2021, 18 (11) : 2038 - 2053
  • [6] Ayer RE, 2008, ACTA NEUROCHIR SUPPL, V104, P33
  • [7] Specific miRNA Disease Biomarkers in Blood, Serum and Plasma: Challenges and Prospects
    Backes, Christina
    Meese, Eckart
    Keller, Andreas
    [J]. MOLECULAR DIAGNOSIS & THERAPY, 2016, 20 (06) : 509 - 518
  • [8] Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
    Bakker, Mark K.
    van der Spek, Rick A. A.
    van Rheenen, Wouter
    Morel, Sandrine
    Bourcier, Romain
    Hostettler, Isabel C.
    Alg, Varinder S.
    van Eijk, Kristel R.
    Koido, Masaru
    Akiyama, Masato
    Terao, Chikashi
    Matsuda, Koichi
    Walters, Robin G.
    Lin, Kuang
    Li, Liming
    Millwood, Iona Y.
    Chen, Zhengming
    Rouleau, Guy A.
    Zhou, Sirui
    Rannikmae, Kristiina
    Sudlow, Cathie L. M.
    Houlden, Henry
    van den Berg, Leonard H.
    Dina, Christian
    Naggara, Olivier
    Gentric, Jean-Christophe
    Shotar, Eimad
    Eugene, Francois
    Desal, Hubert
    Winsvold, Bendik S.
    Borte, Sigrid
    Johnsen, Marianne Bakke
    Brumpton, Ben M.
    Sandvei, Marie Softeland
    Willer, Cristen J.
    Hveem, Kristian
    Zwart, John-Anker
    Verschuren, W. M. Monique
    Friedrich, Christoph M.
    Hirsch, Sven
    Schilling, Sabine
    Dauvillier, Jerome
    Martin, Olivier
    Winsvold, Bendik S.
    Winsvold, Bendik S.
    Borte, Sigrid
    Johnsen, Marianne Bakke
    Brumpton, Ben M.
    Sandvei, Marie Softeland
    Willer, Cristen J.
    [J]. NATURE GENETICS, 2020, 52 (12) : 1303 - 1313
  • [9] Function of microRNA-375 and microRNA-124a in pancreas and brain
    Baroukh, Nadine N.
    Van Obberghen, Emmanuel
    [J]. FEBS JOURNAL, 2009, 276 (22) : 6509 - 6521
  • [10] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
    Bartel, David P.
    [J]. CELL, 2007, 131 (04) : 11 - 29