Effect of vitamin D supplementation on various parameters in patients with non-alcoholic fatty liver disease: An updated meta-analysis

被引:0
作者
Li, Dongdong [1 ]
Fu, Ningtao [2 ]
Wu, Hui [3 ,4 ]
机构
[1] Karamay Cent Hosp Xinjiang, Dept Orthoped, Karamay, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Nutr, Changsha, Peoples R China
[3] Shanghai Healink Med Informat Consulting Co LTD, Res Ctr, Shanghai, Peoples R China
[4] Shanghai Healink Med Informat Consulting Co Ltd, Res Ctr, 258 Pingyang Rd, Shanghai 201102, Peoples R China
关键词
vitamin D; NAFLD; liver enzyme; biochemical indices; randomized controlled trials; meta-analysis; CALCIUM; PHOSPHORYLATION; STEATOHEPATITIS;
D O I
10.5114/ceh.2023.133194
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Aim of the study: The current updated meta-analysis aimed to explore the effects of vitamin D supplementation on various parameters in patients with non-alcoholic fatty liver disease (NAFLD), using the latest trials available.Material and methods: PubMed, Embase, and the Cochrane Library were screened for the collection of randomized controlled trials (RCTs) that compared the efficacy of additional vitamin D vs. the placebo group on NAFLD patients in the last 5 years. Trials included were focused on the assessment of anthropometric and biochemical indices.Results: Our results revealed that additional vitamin D greatly increased serum 25-hydroxyvitamin D (25(OH)D), and decreased the low-density lipoprotein-cholesterol (LDL-C) levels. However, no significant differences were found in terms of triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), c-glutamyltransferase, fast-ing blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR) and Ca2+ levels between the supplementation of vitamin D and placebo.Conclusions: The present study demonstrated the advantageous impact of supplementary vitamin D on the lev-els of 25(OH)D and LDL-C in NAFLD patients. However, the results failed to provide evidence for the superiority of additional vitamin D in relation to the concentrations of serum ALP, AST, TC, Ca, gamma-glutamyl transferase (GGT), TC, FBG, IR and HDL-C.
引用
收藏
页码:396 / 404
页数:9
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