Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review

被引:0
|
作者
Sekulovski, Metodija [1 ,2 ]
Mileva, Niya [3 ]
Chervenkov, Lyubomir [4 ]
Peshevska-Sekulovska, Monika [2 ,5 ]
Vasilev, Georgi Vasilev [2 ,6 ]
Vasilev, Georgi Hristov [2 ,7 ]
Miteva, Dimitrina [2 ,8 ]
Tomov, Latchezar [2 ,9 ]
Lazova, Snezhina [2 ,10 ,11 ]
Gulinac, Milena [2 ,12 ]
Velikova, Tsvetelina [2 ]
机构
[1] Univ Hosp Lozenetz, Dept Anesthesiol & Intens Care, 1 Kozyak Str, Sofia 1407, Bulgaria
[2] Sofia Univ, Med Fac, St Kliment Ohridski, Kozyak 1 Str, Sofia 1407, Bulgaria
[3] Med Univ Sofia, Med Fac, Dept Pharmacol & Toxicol, 1 Georgi Sofiiski Str, Sofia 1431, Bulgaria
[4] Med Univ Plovdiv, Dept Diagnost Imaging, Bul Vasil Aprilov 15A, Plovdiv 4000, Bulgaria
[5] Univ Hosp Lozenetz, Dept Gastroenterol, Sofia 1407, Bulgaria
[6] UMHAT Sv Georgi, Clin Endocrinol & Metab Disorders, Plovdiv 4000, Bulgaria
[7] Natl Specialized Hosp Act Treatment Hematol Dis, Lab Hematopathol & Immunol, Plovdivsko Pole Str, 6, Sofia 1756, Bulgaria
[8] Sofia Univ St Kliment Ohridski, Dept Genet, Fac Biol, 8 Dragan Tzankov Str, Sofia 1164, Bulgaria
[9] New Bulgarian Univ, Dept Informat, Montevideo 21 Str, Sofia 1618, Bulgaria
[10] Univ Hosp NI Pirogov, Pediat Clin, 21 Gen Eduard I Totleben Blvd, Sofia 1606, Bulgaria
[11] Med Univ Sofia, Fac Publ Hlth Prof Tsekomir Vodenicharov, Dept Healthcare, Bialo More 8 Str, Sofia 1527, Bulgaria
[12] Med Univ Plovdiv, Dept Gen & Clin Pathol, Bul Vasil Aprilov 15A, Plovdiv 4000, Bulgaria
关键词
endothelial dysfunction; pregnant women; pregnancy; COVID-19; SARS-CoV-2; infection; thrombophilia; PREECLAMPSIA; ARTERY; GROWTH; ASSOCIATION; THERAPY; WOMEN; BORN;
D O I
10.3390/biomedicines11092458
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal-fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reactions. In this narrative review, we focus on endothelial dysfunction (ED) in pregnancy, associated with obstetric complications, such as preeclampsia, fetal growth retardation, gestational diabetes, etc., and SARS-CoV-2 infection in pregnant women that can cause ED itself and overlap with other pregnancy complications. We also discuss some shared mechanisms of SARS-CoV-2 pathophysiology and ED.
引用
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页数:14
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