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Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review
被引:0
|作者:
Sekulovski, Metodija
[1
,2
]
Mileva, Niya
[3
]
Chervenkov, Lyubomir
[4
]
Peshevska-Sekulovska, Monika
[2
,5
]
Vasilev, Georgi Vasilev
[2
,6
]
Vasilev, Georgi Hristov
[2
,7
]
Miteva, Dimitrina
[2
,8
]
Tomov, Latchezar
[2
,9
]
Lazova, Snezhina
[2
,10
,11
]
Gulinac, Milena
[2
,12
]
Velikova, Tsvetelina
[2
]
机构:
[1] Univ Hosp Lozenetz, Dept Anesthesiol & Intens Care, 1 Kozyak Str, Sofia 1407, Bulgaria
[2] Sofia Univ, Med Fac, St Kliment Ohridski, Kozyak 1 Str, Sofia 1407, Bulgaria
[3] Med Univ Sofia, Med Fac, Dept Pharmacol & Toxicol, 1 Georgi Sofiiski Str, Sofia 1431, Bulgaria
[4] Med Univ Plovdiv, Dept Diagnost Imaging, Bul Vasil Aprilov 15A, Plovdiv 4000, Bulgaria
[5] Univ Hosp Lozenetz, Dept Gastroenterol, Sofia 1407, Bulgaria
[6] UMHAT Sv Georgi, Clin Endocrinol & Metab Disorders, Plovdiv 4000, Bulgaria
[7] Natl Specialized Hosp Act Treatment Hematol Dis, Lab Hematopathol & Immunol, Plovdivsko Pole Str, 6, Sofia 1756, Bulgaria
[8] Sofia Univ St Kliment Ohridski, Dept Genet, Fac Biol, 8 Dragan Tzankov Str, Sofia 1164, Bulgaria
[9] New Bulgarian Univ, Dept Informat, Montevideo 21 Str, Sofia 1618, Bulgaria
[10] Univ Hosp NI Pirogov, Pediat Clin, 21 Gen Eduard I Totleben Blvd, Sofia 1606, Bulgaria
[11] Med Univ Sofia, Fac Publ Hlth Prof Tsekomir Vodenicharov, Dept Healthcare, Bialo More 8 Str, Sofia 1527, Bulgaria
[12] Med Univ Plovdiv, Dept Gen & Clin Pathol, Bul Vasil Aprilov 15A, Plovdiv 4000, Bulgaria
关键词:
endothelial dysfunction;
pregnant women;
pregnancy;
COVID-19;
SARS-CoV-2;
infection;
thrombophilia;
PREECLAMPSIA;
ARTERY;
GROWTH;
ASSOCIATION;
THERAPY;
WOMEN;
BORN;
D O I:
10.3390/biomedicines11092458
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal-fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reactions. In this narrative review, we focus on endothelial dysfunction (ED) in pregnancy, associated with obstetric complications, such as preeclampsia, fetal growth retardation, gestational diabetes, etc., and SARS-CoV-2 infection in pregnant women that can cause ED itself and overlap with other pregnancy complications. We also discuss some shared mechanisms of SARS-CoV-2 pathophysiology and ED.
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页数:14
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