Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review

被引：0

作者：

Sekulovski, Metodija ^{[1
,2
]}

Mileva, Niya ^{[3
]}

Chervenkov, Lyubomir ^{[4
]}

Peshevska-Sekulovska, Monika ^{[2
,5
]}

Vasilev, Georgi Vasilev ^{[2
,6
]}

Vasilev, Georgi Hristov ^{[2
,7
]}

Miteva, Dimitrina ^{[2
,8
]}

Tomov, Latchezar ^{[2
,9
]}

Lazova, Snezhina ^{[2
,10
,11
]}

Gulinac, Milena ^{[2
,12
]}

Velikova, Tsvetelina ^{[2
]}

机构：

[1] Univ Hosp Lozenetz, Dept Anesthesiol & Intens Care, 1 Kozyak Str, Sofia 1407, Bulgaria

[2] Sofia Univ, Med Fac, St Kliment Ohridski, Kozyak 1 Str, Sofia 1407, Bulgaria

[3] Med Univ Sofia, Med Fac, Dept Pharmacol & Toxicol, 1 Georgi Sofiiski Str, Sofia 1431, Bulgaria

[4] Med Univ Plovdiv, Dept Diagnost Imaging, Bul Vasil Aprilov 15A, Plovdiv 4000, Bulgaria

[5] Univ Hosp Lozenetz, Dept Gastroenterol, Sofia 1407, Bulgaria

[6] UMHAT Sv Georgi, Clin Endocrinol & Metab Disorders, Plovdiv 4000, Bulgaria

[7] Natl Specialized Hosp Act Treatment Hematol Dis, Lab Hematopathol & Immunol, Plovdivsko Pole Str, 6, Sofia 1756, Bulgaria

[8] Sofia Univ St Kliment Ohridski, Dept Genet, Fac Biol, 8 Dragan Tzankov Str, Sofia 1164, Bulgaria

[9] New Bulgarian Univ, Dept Informat, Montevideo 21 Str, Sofia 1618, Bulgaria

[10] Univ Hosp NI Pirogov, Pediat Clin, 21 Gen Eduard I Totleben Blvd, Sofia 1606, Bulgaria

[11] Med Univ Sofia, Fac Publ Hlth Prof Tsekomir Vodenicharov, Dept Healthcare, Bialo More 8 Str, Sofia 1527, Bulgaria

[12] Med Univ Plovdiv, Dept Gen & Clin Pathol, Bul Vasil Aprilov 15A, Plovdiv 4000, Bulgaria

来源：

BIOMEDICINES | 2023年 / 11卷 / 09期

关键词：

endothelial dysfunction; pregnant women; pregnancy; COVID-19; SARS-CoV-2; infection; thrombophilia; PREECLAMPSIA; ARTERY; GROWTH; ASSOCIATION; THERAPY; WOMEN; BORN;

D O I：

10.3390/biomedicines11092458

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal-fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reactions. In this narrative review, we focus on endothelial dysfunction (ED) in pregnancy, associated with obstetric complications, such as preeclampsia, fetal growth retardation, gestational diabetes, etc., and SARS-CoV-2 infection in pregnant women that can cause ED itself and overlap with other pregnancy complications. We also discuss some shared mechanisms of SARS-CoV-2 pathophysiology and ED.

引用

页数：14

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